Fatigue pp 429-456 | Cite as

Fatigue in Adapted Systems

Overuse and Underuse Paradigms
  • T. Gordon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 384)

Abstract

Alterations in structural and biochemical properties of muscles that underlie physiological parameters of contractile force, speed and fatigability are described under conditions of 1) overuse: imposed electrical stimulation, natural exercise and functional overload; 2) reinnervation of denervated muscles; and 3) underusage: conditions of restricted use after spinal cord injury, weightlessness, immobilization and drug-induced neuromuscular blockade. These conditions demonstrate the remarkable plasticity of muscle fibers with obvious implications in health and disease. They also identify that the amount of neuromuscular activity and loading of muscle contractions are major factors determining susceptibility to fatigue and muscle strength, respectively.

Keywords

Motor Unit Endurance Training Soleus Muscle Medial Gastrocnemius Apply Physiology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • T. Gordon
    • 1
  1. 1.Department of Pharmacology, Division of NeurosciencesUniversity of AlbertaEdmontonCanada

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