Molecular and Genetic Insights Into T Cell Antigen Receptor Signal Transduction

  • Arthur Weiss
  • Makio Iwashima
  • Bryan Irving
  • Nicolai S. C. van Oers
  • Theresa A. Kadlecek
  • David Straus
  • Andrew Chan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)

Abstract

T lymphocytes are relatively quiescent cells, poised in the G0 stage of the cell cycle, until they encounter antigen. The initiation of an immune response by T cells requires the recognition of antigen by the T cell antigen receptor (TCR) and the conversion of this recognition event into biochemical signals that can induce a cellular response. This cellular response leads to the clonal expansion of antigen-specific differentiated effector T cells.

Keywords

Protein Tyrosine Kinase Antigen Receptor Bovine Leukemia Virus Severe Combine Immunodeficiency Protein Tyrosine Phosphorylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Arthur Weiss
    • 1
  • Makio Iwashima
    • 1
  • Bryan Irving
    • 1
  • Nicolai S. C. van Oers
    • 1
  • Theresa A. Kadlecek
    • 1
  • David Straus
    • 1
  • Andrew Chan
    • 2
  1. 1.Departments of Medicine and of Microbiology and Immunology, Howard Hughes Medical InstituteUniversity of California, San FranciscoSan FranciscoUSA
  2. 2.Department of Medicine, Howard Hughes Medical InstituteWashington University School of MedicineSt. LouisUSA

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