Analysis of the (YXXL/I)2 Signalling Motifs Found in the Cytoplasmic Segment of the Mouse CD3-ζ Chain

  • Anne-Marie K. Wegener
  • Bernard Malissen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 365)

Abstract

The specific recognition of antigen by T cells and its ensuing transduction into intracellular signals is accomplished by the T cell antigen receptor (TCR)-CD3 complex. The transducing subunits of this multimolecular complex, termed CD-3-γ, -δ, -ϵ, -ζ and -η, are noncovalently associated with the antigen binding TCR αβ (or TCR γδ) dimer. They possess large intracytoplasmic segments which are responsible for their signalling properties and made of a recurrent functional domain of ~20 amino acids. Common to each copy of this domain is a pair of Tyr-X-X-Leu/Ile sequences (where X corresponds to a variable residue) separated by seven or eight variable residues. This consensus sequence, hereafter referred to as the (YXXL/I)2 motif, is expressed as a single copy in the cytoplasmic tail of the CD3-δ, CD3-γ and CD3-ϵ subunits.1 The CD3-ζ polypeptide appears to be unique among this set of signalling devices in the sense that it displays three concatenated copies of the (YXXL/I)2 motif (denoted as ζa, ζb, and ζc).2

Keywords

Cytoplasmic Tail Cell Antigen Receptor Variable Residue Multimolecular Complex Cytoplasmic Segment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Anne-Marie K. Wegener
    • 1
  • Bernard Malissen
    • 1
  1. 1.Centre d’Immunologie INSERM-CNRS de Marseille-LuminyMarseille Cedex 9France

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