Regulation of Angiotensin II Receptor Expression in Ovarian Follicles

A Review
  • A. H. Nielsen
  • A. Hagemann
  • B. Svenstrup
  • J. Nielsen
  • K. Poulsen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 377)

Summary

The regulation of angiotensin (Ang) II receptor expression in ovarian follicles was reviewed. Ang II receptor expression, assessed as the Ang II binding capacity, varied with the animal species and the developmental stage of the follicle. In cows, the expression correlated positively with follicular size and negatively with the active renin concentration in the follicular wall tissue. No relations were found to the follicular fluid concentrations of prorenin, estradiol or progesterone. In cell cultures, luteinizing hormone up-regulated Ang II receptor expression in cows, whereas it was decreased by follicle-stimulating hormone, Ang II and testosterone in rats.

These data support the concept of an active and regulated RAS in ovarian follicles. The species differences in Ang II expression suggest varying functional roles of the RAS between species.

Keywords

Luteinizing Hormone Granulosa Cell Follicular Fluid Ovarian Follicle Atretic Follicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aguilera G, Millan MA, Harwood JP. Angiotensin II receptors in the gonads. Am J Hypertens 1989; 2: 395–402.PubMedGoogle Scholar
  2. Brunswigs-Spickenheier B, Mukhopadhyay AK. Characterization of angiotensin-II receptor subtype on bovine thecal cells and its regulation by luteinizing hormone. Endocrinology 1992; 131: 1445–1452.CrossRefGoogle Scholar
  3. Daud AI, Bumpus FM, Husain A. Evidence for selective expression of angiotensin II receptors on atretic follicles in the rat ovary: an autoradiographic study. Endocrinology 1988; 122: 2727–2734.PubMedCrossRefGoogle Scholar
  4. Husain A, Bumpus FM, De Silva P, Speth RC. Localization of angiotensin II receptors in ovarian follicles and the identification of angiotensin II in rat ovaries. Proc Natl Acad Sci USA 1987; 84: 2489–2493.PubMedCrossRefGoogle Scholar
  5. Ireland JJ, Roche JF. Growth and differentiation of large antral follicles after spontanous luteolysis in heifers: change in concentration of hormones in follicular fluid and specific binding of gonadotropins to follicles. J Animal Sci 1983; 57: 157–167.Google Scholar
  6. Kambayashi Y, Bardhan S, Takahashi K, Tsuzuki S, Inui H, Hamakubo T, Inagami T. Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem 1993; 268: 24543–24546.PubMedGoogle Scholar
  7. Kuo TC, Endo K, Dharmarajan AM, Miyazaki T, Atlas SJ, Wallach EE. Direct effect of angiotensin II on in-vitro perfused rabbit ovary. J Reproduc Fertil 1991; 92: 469–474.CrossRefGoogle Scholar
  8. Lightman A, Jones CL, MacLusky NJ, Palumbo A, DeCherney AH, Naftolin F. Immunocytochemical localization of angiotensin II immunoreactivity and demonstration of angiotensin II binding in the rat ovary. Am J Obstet Gynecol 1988, 159: 526–530.PubMedGoogle Scholar
  9. Lumbers ER. The ovary. In: Robertson JIS, Nicholls MG, eds. The renin-angiotensin system. Gower Medical Publishing, London, 1993:46.1–46.12.Google Scholar
  10. Mukhopadhyay AK, Holstein K, Szkudlinski M, Brunswig-Spickenheier B, Leidenberger FA. The relationship between prorenin levels in follicular fluid and follicular atresia in bovine ovaries. Endocrinology 1991; 129: 2367–2375.PubMedCrossRefGoogle Scholar
  11. Nielsen AH, Hagemann A, Svenstrup B, Nielsen J, Poulsen K. Angiotensin II receptor density in bovine ovarian follicles relates to tissue renin and follicular size. Clin Exp Pharmacol Physiol 1994; 21: 463–469.PubMedCrossRefGoogle Scholar
  12. Pellicer A, Palumbo A, DeCherney AH, Naftolin F. Blockage of ovulation by an angiotensin antagonist. Science 1988; 240: 1660–1661.PubMedCrossRefGoogle Scholar
  13. Peterson CM, Zhu C, Mukaida T, Butler TA, Woessner JFJ, LeMaire WJ. The angiotensin II antagonist saralasin inhibits ovulation in the perfused rat ovary. Am J Obstet Gynecol 1993; 168: 242–245.PubMedCrossRefGoogle Scholar
  14. Pucell AG, Bumpus FM, Husain A. Rat ovarian angiotensin II receptors. Characterization and coupling to estrogen secretion. J Biol Chem 1987; 262: 7076–7080.Google Scholar
  15. Pucell AG, Bumpus FM, Husain A. Regulation of angiotensin II receptors in cultured rat ovarian granulosa cells by follicle-stimulating hormone and angiotensin II. J Biol Chem 1988; 263: 11954–11961.PubMedGoogle Scholar
  16. Pucell AG, Hodges JC, Sen I, Bumpus FM, Husain A. Biochemical properties of the ovarian granulosa cell type 2-angiotensin II receptor. Endocrinology 1991; 128: 1947–1959.PubMedCrossRefGoogle Scholar
  17. Rainey WE, Bird JM, Byrd W, Carr BR. Effect of angiotensin II on human luteinized granulosa cells. Fertil Steril 1993; 59: 143–147.PubMedGoogle Scholar
  18. Schultze D, Brunswig B, Mukhopadhyay AK. Renin and prorenin-like activities in bovine ovarian follicles. Endocrinology 1989; 124: 1389–1398.PubMedCrossRefGoogle Scholar
  19. Speth RC, Bumpus FM, Husain A. Identification of angiotensin II receptors in the rat ovary. Eur J Pharmacol 1986; 130: 351–352.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • A. H. Nielsen
    • 1
  • A. Hagemann
    • 1
  • B. Svenstrup
    • 2
  • J. Nielsen
    • 2
  • K. Poulsen
    • 1
  1. 1.Department of Anatomy and PhysiologyThe Royal Veterinary and Agricultural UniversityFrederiksberg CDenmark
  2. 2.Department of Clinical BiochemistryStatens SeruminstitutCopenhagen SDenmark

Personalised recommendations