Regulation of Angiotensin II Receptor Expression in Ovarian Follicles
The regulation of angiotensin (Ang) II receptor expression in ovarian follicles was reviewed. Ang II receptor expression, assessed as the Ang II binding capacity, varied with the animal species and the developmental stage of the follicle. In cows, the expression correlated positively with follicular size and negatively with the active renin concentration in the follicular wall tissue. No relations were found to the follicular fluid concentrations of prorenin, estradiol or progesterone. In cell cultures, luteinizing hormone up-regulated Ang II receptor expression in cows, whereas it was decreased by follicle-stimulating hormone, Ang II and testosterone in rats.
These data support the concept of an active and regulated RAS in ovarian follicles. The species differences in Ang II expression suggest varying functional roles of the RAS between species.
KeywordsLuteinizing Hormone Granulosa Cell Follicular Fluid Ovarian Follicle Atretic Follicle
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- Ireland JJ, Roche JF. Growth and differentiation of large antral follicles after spontanous luteolysis in heifers: change in concentration of hormones in follicular fluid and specific binding of gonadotropins to follicles. J Animal Sci 1983; 57: 157–167.Google Scholar
- Lumbers ER. The ovary. In: Robertson JIS, Nicholls MG, eds. The renin-angiotensin system. Gower Medical Publishing, London, 1993:46.1–46.12.Google Scholar
- Pucell AG, Bumpus FM, Husain A. Rat ovarian angiotensin II receptors. Characterization and coupling to estrogen secretion. J Biol Chem 1987; 262: 7076–7080.Google Scholar