Chemopreventative Activity of Chlorophyllin: Inhibition of Mutagenicity and Covalent DNA Binding of Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide
A variety of plant and vegetable constituents have been found to possess substantial inhibitory effects against some chemical carcinogens and mutagens. One of the major antimutagenic factors in plant and vegetable extracts is chlorophyll. Because of the insolubility of chlorophyll, its water soluble sodium/copper salt, chlorophyllin (CHL), has been used as an alternative in studying the biological effects of chlorophyll. CHL strongly inhibits the genotoxicity of certain environmental mutagens. However, mechanisms by which CHL exerts its antimutagenic effects remain unclear.