Vitamin-Regulated Retinoblastoma Tumor Suppressor Gene Expression in Leukemic Cells

  • Andrew Yen
  • Tracy French
  • Karen Russell
  • Susi Varvayanis
  • Mary Forbes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 375)

Abstract

Vitamins A and D are well known to perform important functions in growth and development. The mechanisms by which they act at the cellular level to control proliferation and differentiation thus become of importance in understanding how these dietary factors work. Using tissue culture, it has been found that a variety of cultured cells respond in particular to the metabolites, retinoic acid, and 1,25-dihydroxy vitamin D3. These cells have formed convenient experimental systems in which to study the mechanism of action of these metabolites at the molecular level. At this level, it is known that vitamins A and D have receptors that are related as members of the family of steroid-thyroid hormone receptors.1,2 Ligand receptor binding and receptor complex translocation to the nucleus thus regulate gene expression. The ultimate result of a lengthy metabolic cascade initiated this way can be control of cell proliferation or differentiation. The identity and roles of the genes that mediate this metabolic cascade are of obvious interest in understanding the mechanism by which these vitamins or their metabolites act in growth and development.

Keywords

Retinoic Acid Specific Growth Arrest Metabolic Cascade Retinoblastoma Gene Product Nuclear Oncogene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Andrew Yen
    • 1
  • Tracy French
    • 1
  • Karen Russell
    • 1
  • Susi Varvayanis
    • 1
  • Mary Forbes
    • 1
  1. 1.Cancer Biology Laboratories, Department of Pathology, College of Veterinary MedicineCornell UniversityIthacaUSA

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