Urolithiasis pp 247-247 | Cite as

Decreased Erythrocyte Glycosaminoglycan Content in Idiopathic Calcium-Oxalate Nephrolithiasis

  • B. Baggio
  • G. Marzaro
  • G. Gambaro
  • F. Marchini
  • E. Cicerello
  • S. Mastrosimone
  • H. E. Williams
  • A. Borsatti

Abstract

In red blood cells (RBC) of idiopathic calcium-oxalate stone formers (ISF), we previously demonstrated an abnormal transmembrane self-exchange (SE) of oxalate (1). The molecular basis of this anomaly seems to be an altered phosphorylation state of band-3 protein, the anion-carrier, probably resulting from an increased activity of protein kinases (2). Since glycosaminoglycans (GAG) are known inhibitors of protein kinases, we tested the hypothesis that a fall in GAG concentration in RBC membranes might be responsible for the increased phosphorylation of band-3 protein.

Keywords

Protein Kinase Negative Correlation Membrane Protein Molecular Basis Significant Negative Correlation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    B Baggio, G Gambaro, F Marchini, E Cicerello, R Tenconi, M Clementi, and A Borsatti, NEJM 314: 599 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    B Baggio, G Clari, G Marzaro, G Gambaro, A Borsatti, and V Moret, Contr. Nephrol. 58: 156 (1987).Google Scholar
  3. 3.
    P Whiteman, Biochem. J. 131: 343 (1973).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • B. Baggio
    • 1
  • G. Marzaro
    • 1
  • G. Gambaro
    • 1
  • F. Marchini
    • 1
  • E. Cicerello
    • 1
  • S. Mastrosimone
    • 1
  • H. E. Williams
    • 1
  • A. Borsatti
    • 1
  1. 1.Institute of Internal MedicineUniversity of PadovaPadovaItaly

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