Urolithiasis pp 217-218 | Cite as

Urinary Excretion of Lithogenic Substances and Inhibitory Activity Towards Calcium-Oxalate-Monohydrate Crystal Growth in Idiopathic Urolithiasis

  • D. Wangoo
  • H. Sidhu
  • S. Vaidyanathan
  • V. Rattan
  • S. K. Thind
  • R. Nath
  • G. C. Malakondaiah
  • K. Krishan
  • G. S. Gupta

Abstract

Calculus formation occurs in urine supersaturated with Ca, oxalate (Ox), phosphate (Pi), and uric acid (UA) (1). The calculated degrees of supersaturation have been used to estimate risk factors for the probably formation of renal stones. Normal urine contains a variety of inhibitory substances which may prevent or retard the precipitation of these lithogenic substances in the urinary tract. These inhibitors include components like citrate, isocitrate, pyrophosphate, magnesium polyacidic peptides, and a variety of polyanionic compounds as well. The present study is concerned with the inhibitory activity (IA) and urinary excretion of lithogenic substances, and examines possible correlations between urinary UA levels and urinary inhibitory activity towards CaOx-monohydrate (COM) crystal growth.

Keywords

Uric Acid Uric Acid Level Calcium Oxalate Calcium Oxalate Stone CaOx Crystal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    WG Robertson, M Peacock, RW Marshall, DH Marshall, and BEC Nordin, Saturation inhibition index as a measure of the risk of calcium oxalate stone formation in the urinary tract, NEJM 294: 249 (1976).PubMedCrossRefGoogle Scholar
  2. 2.
    FL Coe, HC Mangatis, LH Deutsch, and AL Strauss, Urinary macromolecular crystal growth inhibitors in calcium nephrolithiasis, Mineral Electrolyte Metab. 3: 268 (1980).Google Scholar
  3. 3.
    FL Coe, Hyperuricosuric calcium oxalate nephrolithiasis, Kidney Int. 13: 418 (1978).PubMedCrossRefGoogle Scholar
  4. 4.
    H Sidhu, S Vaidyanathan, D Wangoo, V Rattan, SK Thind, R Nath, GC Malakondaiah, and SP Tandon, Urinary inhibitory activity of calcium oxalate monohydrate crystal growth in stone formers and non-stone formers, Indian J. Med. Res. 86: 500 (1987).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • D. Wangoo
    • 2
  • H. Sidhu
    • 1
  • S. Vaidyanathan
    • 3
  • V. Rattan
    • 1
  • S. K. Thind
    • 1
  • R. Nath
    • 1
  • G. C. Malakondaiah
    • 3
  • K. Krishan
    • 4
  • G. S. Gupta
    • 2
  1. 1.Department of BiochemistryPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of BiophysicsPunjab UniversityChandigarhIndia
  3. 3.Department of UrologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  4. 4.Department of StatisticsPunjab UniversityChandigarhIndia

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