Effective Prevention of Calcium-Oxalate Crystal Formation in vitro and in vivo by Pentosan Polysulfate
The “inhibitor theory” as an alternative to the “matrix theory” postulates that stone-forming patients have a deficiency of effective inhibitors of crystal growth in their urine (1). A number of inhibitors of calcium-oxalate (CaOx) crystal formation have been described including pentosan polysulfate (2). Since Danielson et al. (3) reported the possible efficacy of pentosan polysulfate (PPS) in reducing the recurrence rate of CaOx stone formation in man, it was of interest to establish a test system with in vitro and in vivo experiments that allow quantitation of the assumed beneficial effects of PPS. In addition, a reliable test system can provide the basis for a systematic search for effective inhibitors of CaOx crystal formation in the kidney and urine. For comparison we also studied three types of chondroitin sulfate in vivo and in vitro.
KeywordsChondroitin Sulfate Calcium Oxalate CaOx Crystal Pentosan Polysulfate Lithogenic Diet
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