Urolithiasis pp 137-139 | Cite as

Nephrocalcin Isolated from Human Kidney Stones is a Defective Calcium-Oxalate-Monohydrate Crystal-Aggregation Inhibitor

  • B. Hess
  • Y. Nakagawa
  • F. L. Coe

Abstract

Calcium kidney stone formers (SF) excrete nephrocalcin (NC) that lacks γ-carboxyglutamic acid (Gla) and has weak amphiphillic properties (1). Urinary NC from SF (sf NC) has a low affinity for calcium oxalate monohydrate (COM) crystals and inhibits their growth less than normal urinary NC (n NC) (1). Nephrocalcin isolated from human calcium kidney stones (stone NC) has the same structural defects as sf NC, but inhibits COM crystal growth as well as n NC (2). Since kidney stones can form by aggregation of small crystals whose growth has been retarded, stone NC could fail to prevent stone formation because of reduced inhibition of COM crystal aggregation.

Keywords

Zeta Potential Kidney Stone Calcium Oxalate Calcium Oxalate Mono Calcium Oxalate Monohydrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Y Nakagawa, V Abram, JH Parks, HS-H Lau, JH Kawooya, and FL Coe, Urine glycoprotein crystal growth inhibitors: evidence for a molecular abnormality in calcium oxalate nephrolithiasis, J. Clin. Invest. 76: 1455 (1985).PubMedCrossRefGoogle Scholar
  2. 2.
    Y Nakagawa, MA Ahmed, SL Hall, S Deganello, and FL Coe, Isolation from human calcium oxalate renal stones of nephrocalcin, a glycoprotein inhibitor of calcium oxalate crystal growth: evidence that nephrocalcin from patients with calcium oxalate nephrolithiasis is deficient in γ-carboxyglutamic acid, J. Clin. Invest. 79: 1782 (1987).PubMedCrossRefGoogle Scholar
  3. 3.
    B Hess, Y Nakagawa, and FL Coe, New spectrophotometric method for measuring aggregation of calcium oxalate monohydrate crystals in the absence of supersaturation, in: this volume, p. 55.Google Scholar
  4. 4.
    Y Nakagawa, V Abram, F Kezdy, ET Kaiser, and FL Coe, Purification and characterization of the principal inhibitor of calcium oxalate monohydrate crystal growth in human urine, J. Biol. Chem. 258: 12594 (1983).PubMedGoogle Scholar
  5. 5.
    H Fleisch, Inhibitors and promoters of stone formation, Kidney Int. 13: 361 (1978).PubMedCrossRefGoogle Scholar
  6. 6.
    B Finlayson, Physicochemical aspects of urolithiasis, Kidney Int. 13: 344 (1978).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • B. Hess
    • 1
    • 2
  • Y. Nakagawa
    • 1
  • F. L. Coe
    • 1
  1. 1.Nephrology ProgramUniversity of ChicagoChicagoUSA
  2. 2.Department of MedicineUniversity of ZurichZurichSwitzerland

Personalised recommendations