It is generally agreed that crystal nucleation during urolithiasis is heterogeneous. However, the nature of these nucleators is still unknown. Membrane lipids have been histochemically and biochemically demonstrated at physiological as well as pathological calcification sites (1) and have been implicated in nucleation of crystals in a number of bio-mineralization systems. Acidic phospholipids and lipid extracts from calcified tissues have been shown to initiate in vitro calcium phosphate formation from metastable calcium phosphate solutions (1). We have recently demonstrated the presence of lipids in various types of human urinary stones (2). In the present study, we will present additional information regarding lipids of calcium oxalate stones.
KeywordsCalcium Oxalate Choline Phosphatidyl Urinary Stone Ethanolamine Phosphatidyl Calcium Oxalate Stone
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- 1.AL Boskey, Current concepts of the physiology and biochemistry of calcification, Clin. Orthopaedics 157: 225 (1981).Google Scholar