The Possibility of a Specific Calcium Sensor/Receptor Function of Proximal Renal Tubular Cells

  • B. Fellström
  • C. Juhlin
  • H. Johansson
  • L. Klareskog
  • S. Ljunghall
  • J. Rastad
  • G. Akerström

Abstract

Disturbances of calcium metabolism are well documented in renal calcium-stone disease and hypercalciuria is the most commonly-occurring metabolic deviation (1). Idiopathic hypercalciuria is considered to be caused by an increased gastrointestinal absorption of calcium, whereas a primary renal leak of calcium with the development of secondary hyperparathyroidism (HPT) is unusual, as judged by present diagnostic tools.

Keywords

Proximal Tubule Tubular Cell Parathyroid Adenoma Extracellular Calcium Proximal Tubular Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    S Ljunghall, U Backman, BG Danielson, B Fellström, G Johansson, and B Wikström, Calcium metabolism in renal stone disease, Scand. J. Urol. Nephrol. (Suppl.) 53:111 (1980).Google Scholar
  2. 2.
    WN Suki, Calcium transport in the nephron, Am. J. Physiol. 237:F1 (1979).PubMedGoogle Scholar
  3. 3.
    RAL Sutton-and JH Dirks, Renal handling of calcium, phosphate, and magnesium, in: “The Kidney,” B Brenner and F Rector, eds., Saunders (1981).Google Scholar
  4. 4.
    C Juhlin, R Holmdahl, H Johansson, J Rastad, G Akerström, and L Klareskog, Monoclonal antibodies with exclusive reactivity against parathyroid cells and tubular cells of the kidney, PNAS 84:2990 (1987).PubMedCrossRefGoogle Scholar
  5. 5.
    C Juhlin, H Johansson, R Holmdahl, E Gylfe, R Larsson, J Rastad, G Akerström, and L Klareskog, Monoclonal anti-parathyroid antibodies interfering with a Ca2+-sensor of human parathyroid cells, BBRC 143:570 (1987).PubMedGoogle Scholar
  6. 6.
    KA Hruska, M Goligorsky, J Scobbe, M Tsutsumi, S Westbrook, and D Moskowitz, Effects of parathyroid hormone on cytosolic calcium in renal proximal tubular primary cultures, Am. J. Physiol. 251:F188 (1986).PubMedGoogle Scholar
  7. 7.
    BA Kruskal, CH Keith, and FR Maxfield, Thyrotropin-releasing-hormoneinduced changes in intracellular Ca2+ measured by microspectrofluorometry on individual quin-2 loaded cells, J. Cell Biol. 99:1167 (1984).PubMedCrossRefGoogle Scholar
  8. 8.
    G Grynkiewicz, M Poenie, and RY Tsien, A new generation of Ca2+ indicators with greatly improved fluorescence properties, J. Biol. Chem. 260:3440 (1986).Google Scholar
  9. 9.
    C Juhlin, L Klareskog, P Nygren, S Ljunghall, E Gylfe, J Rastad, and G Akerström, Hyperparathyroidism is associated with reduced expression of a parathyroid calcium receptor mechanism defined by monoclonal antiparathyroid antibodies, Endocrinology 122:2999 (1988).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • B. Fellström
    • 1
  • C. Juhlin
    • 1
  • H. Johansson
    • 1
  • L. Klareskog
    • 1
  • S. Ljunghall
    • 1
  • J. Rastad
    • 1
  • G. Akerström
    • 1
  1. 1.Departments of Internal Medicine, Surgery, and Medical and Physiological ChemistryUniversity HospitalUppsalaSweden

Personalised recommendations