Urolithiasis pp 797-800 | Cite as

Lack of Effect of Thiazide Therapy on Serum 1,25-Dihydroxyvitamin D in Idiopathic Hypercalciuria with Renal Calculi

  • V. Nunziata
  • G. di Giovanni
  • R. Giannattasio
  • M. F. Corrado
  • M. Riccio

Abstract

Thiazide diuretics cause a persistent lowering effect on urinary Ca excretion in normal subjects and in patients with idiopathic hypercalciuria. By reabsorbing ultrafilterable Ca, this drug is considered to have a selective effect in suppressing parathyroid activity, particularly in renal hypercalciuric patients. In association with this, a reduction in serum 1, 25-dihydroxyvitamin D is also found and a decrease in intestinal Ca absorption (1). However, thiazides are reported to have no action on parathyroid hormone - vitamin D feedback in absorptive hypercalciuria because of the believed parathyroid-hormone-independent vitamin D3 increased production rate (1). Moreover, such diuretics have also been shown to reduce the turnover of body Ca (2) which is reported to be significantly increased in unselected people with idiopathic hypercalciuria and kidney stone disease (3). The aim of this study was to assess body Ca turnover and vitamin D serum levels in each of the hypercalciuric subgroups of patients, and to look for modifications in the post-thiazide treatment period.

Keywords

Thiazide Diuretic Total Body Clearance Intestinal Calcium Absorption Idiopathic Hypercalciuria Kidney Stone Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    JE Zerwekh and CYC Pak, Selective effect of thiazide therapy on serum 1α,25 Dihydroxyvitamin D and intestinal calcium absorption in renal and absorptive hypercalciurias, Metabolism 29:13 (1980).PubMedCrossRefGoogle Scholar
  2. 2.
    U Ehrig, JE Harrison, and DR Wilson, Effect of long-term thiazide therapy on intestinal calcium absorption in patients with recurrent renal calculi, Metabolism 23:139 (1974).PubMedCrossRefGoogle Scholar
  3. 3.
    UA Liberman, O Sperling, A Atsmon, M Frank, M Modan, and A de Vries, Metabolic and calcium kinetic studies in idiopathic hypercalciuria, J. Clin. Invest. 47:2580 (1968).PubMedCrossRefGoogle Scholar
  4. 4.
    CYC Pak, RA Kaplan, H Bone, J Townsend, and O Waters, A simple test for the diagnosis of absorptive, resorptive and renal hypercalciurias, NEJM 292:497 (1975).PubMedCrossRefGoogle Scholar
  5. 5.
    M Gibaldi and D Perrier, in: “Pharmacokinetics,” J Swarbrick, ed., M Dekker, Inc., New York (1976).Google Scholar
  6. 6.
    JA Eisman, AJ Hamstra, BE Kream, and HF DeLuca, A sensitive, precise and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma, Arch. Biochem. Biophys. 176:235 (1976).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • V. Nunziata
    • 1
  • G. di Giovanni
    • 1
  • R. Giannattasio
    • 1
  • M. F. Corrado
    • 1
  • M. Riccio
    • 1
  1. 1.Institute of Internal Medicine and Metabolic DiseasesUniversity of NaplesNaplesItaly

Personalised recommendations