Urolithiasis pp 793-795 | Cite as

Correlation Between Recurrence of Nephrolithiasis and Persistence of Bone Resorption in Patients with Recurrent Calcium Nephrolithiasis on Long-Term Thiazide Therapy

  • V. Ortalda
  • A. Fabris
  • A. D’Angelo
  • S. Giannini
  • L. Perobelli
  • G. Maschio

Abstract

Hydrochlorothiazide appears to be the drug of choice in patients with recurrent Ca nephrolithiasis (RCN), even in those with no metabolic disorder (1, 2). Recent research shows evidence of a pathophysiologic role for the most active metabolite of vitamin D, 1, 25(OH)2D in the persistence of hypercalciuria in patients with RCN on thiazide therapy (3, 4).

Keywords

Bone Mineral Content Primary Hyperparathyroidism Urinary Oxalate Urinary Uric Acid Hexuronic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    ER Yendt and M Cohanim, Prevention of calcium stones with thiazides, Kidney Int. 13:397 (1978).PubMedCrossRefGoogle Scholar
  2. 2.
    CYC Pak, P Peters, G Hurt, et al., Is selective therapy of recurrent nephrolithiasis possible? Am. J. Med. 71:615 (1981).PubMedCrossRefGoogle Scholar
  3. 3.
    JJ Lemann, RW Gray, and ND Adams, Vitamin D metabolism in patients with nephrolithiasis, in: “Vitamin D Basic Research and its Clinical Application,” AW Norman and K Schaefer, et al., eds., Walter de Gruyter & Co., New York (1979).Google Scholar
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    JE Zerwekh, and CYC Pak, Selective effects of thiazide therapy on serum 1, 25(OH)2D and intestinal calcium absorption in renal and absorptive hypercalciurias, Metabolism 29:13 (1980).PubMedCrossRefGoogle Scholar
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    A Broadus, KL Insogna, R Lang, LE Mallette, et al., A consideration of the hormonal basis and phosphate leak hypothesis of absorptive hypercalciuria, J. Clin. Endocrinol. Metab. 58: (1984).Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • V. Ortalda
    • 1
  • A. Fabris
    • 1
  • A. D’Angelo
    • 2
  • S. Giannini
    • 2
  • L. Perobelli
    • 3
  • G. Maschio
    • 1
  1. 1.Division of NephrologyInstitute of Internal MedicineItaly
  2. 2.Institute of Internal MedicinePadovaItaly
  3. 3.Laboratory of BiochemistryInstitute of Internal MedicineVeronaGermany

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