Urolithiasis pp 611-613 | Cite as

Response to Exogenous 1,25(OH)2D during a Low-Calcium Diet in Normal Subjects and Idiopathic Renal-Stone Formers

  • J. R. Weisinger
  • E. Bellorín-Font
  • A. Aveledo
  • P. Durrego
  • G. Gonzalez
  • N. Pernalete
  • C. Milanes
  • R. Starosta
  • I. Contreras
  • V. Paz-Martínez

Abstract

A significant number of patients who develop renal stones have evidence of hypercalciuria. It is generally agreed that this increase in urinary calcium excretion is one of the risk factors favoring calcium-oxalate supersaturation, calcium salt precipitation, and stone growth. The mechanisms responsible for the hypercalciuria may involve intestinal calcium absorption, renal-tubular calcium reabsorption, and the regulation of bone mineral content. With the idea of further clarifying the possible pathogenetic mechanisms related to the hypercalciuria, we designed a prospective protocol where we studied normal subjects and a group of renal stone formers before and after the administration of oral 1,25(OH)2D3 (1,25-D). Our results suggest that hypercalciuric renal-stone formers do not have increased sensitivity to exogenous 1,25-D and that other factors besides 1,25-D could be involved in the pathogenesis of hypercalciuria.

Keywords

Normal Subject Bone Mineral Content Renal Stone Urinary Calcium Excretion Intestinal Calcium Absorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    J Lemann, Jr. and RW Gray, Hypercalciuric renal stone formers exhibit enhanced intestinal calcium absorption despite only slightly elevated serum 1,25(OH)2D concentrations, Kidney Int. 33: 343 (1988).Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. R. Weisinger
    • 1
  • E. Bellorín-Font
    • 1
  • A. Aveledo
    • 1
  • P. Durrego
    • 1
  • G. Gonzalez
    • 1
  • N. Pernalete
    • 1
  • C. Milanes
    • 1
  • R. Starosta
    • 1
  • I. Contreras
    • 1
  • V. Paz-Martínez
    • 1
  1. 1.Sección de Investigaciones, Centro Nacional de Diálisis y Transplante, MSAS, and the Division of NephrologyHospital Universitario de CaracasCaracasVenezuela

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