Urolithiasis pp 567-569 | Cite as

Sulfur Amino Acids, Thiol Drugs, and Related Mixed Disulfides from Urine Samples of Cystine Stone Patients

  • C. Martini
  • M. Bruno
  • M. Petrarulo
  • D. Cosseddu
  • F. Linari

Abstract

The evaluation of sulfur-containing amino acids in urine is of interest in cystinuric subjects since the abnormally-high excretion of cystine, a disulfur amino acid, is responsible for the disease. Furthermore, sulfur drugs such as d-penicillamine (PEN) and 2-mercapto-propionyl-glycine (MPG) are often used in the treatment of cystinuric patients on the basis of a thiol-exchange reaction. Some of the resulting compounds appear in urine and their identification is necessary for a full comprehension of urine chromatograms. This study was designed to identify and determine such compounds in the urine of normal subjects and cystine stone patients.

Keywords

Sulfur Amino Acid Lithium Hydroxide Mixed Disulfide Sulfur Drug Full Comprehension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    JA Harbar, DC Cusworth, LC Lawes, and OM Wrong, Comparison of 2-mercapto-propionylglycine and d-penicillamine in the treatment of cystinuria, J. Urol. 136: 146 (1986).PubMedGoogle Scholar
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    JS King, Jr., Treatment of cystinuria with α-mercaptopropionyl-glycine: a preliminary report with some notes on column chromatography of mercaptans, Proc. Soc. Exptl. Med. 129: 927 (1968).CrossRefGoogle Scholar
  3. 3.
    GW Frimpter, The disulfide of 1-cysteine and 1-homocysteine in urine of patients with cystinuria, J. Biol. Chem. 236-.PC 51 (1961).Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • C. Martini
    • 1
  • M. Bruno
    • 1
  • M. Petrarulo
    • 1
  • D. Cosseddu
    • 1
  • F. Linari
    • 1
  1. 1.Renal Stone LaboratoryOspedale Mauriziano Umberto ITorinoItaly

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