The metabolism of citrate has been a prominent topic in biochemistry since the discovery of the tricarboxylic acid cycle by Krebs in the 1930’s. However, as a subject of clinical interest, renal citrate excretion and metabolism have only recently come into vogue. The current interest in this subject arises from recent emphasis on the role of decreased citrate excretion in the pathogenesis of urolithiasis, and from the use of potassium citrate in treating certain types of recurrent stone formation.
KeywordsBrush Border Brush Border Membrane Tricarboxylic Acid Cycle Metabolic Alkalosis Potassium Citrate
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