Urolithiasis pp 481-483 | Cite as

Hydroxycarboxylate Malabsorption and Calcium Oxalate Nephrolithiasis

  • D. M. Cowley
  • J. M. Brown
  • B. C. McWhinney
  • A. H. Chalmers

Abstract

In Queensland, Australia, there is a high incidence of calcium nephrolithiasis (16.8 hospital admissions per 10,000 population) which is among the highest incidences reported for Westernized societies (1). Our initial investigation of 40 recurrent calcium-oxalate stone formers indicated that they have significantly elevated urinary oxalate and calcium excretions and decreased excretions of ascorbate and citrate (1). The raised oxalate excretion was shown not to be due to a hyperactive 2-carbon pathway, or to be derived from fat or carbohydrate metabolism (2).

Keywords

Calcium Excretion Urinary Calcium Excretion Urinary Oxalate Potassium Citrate Stone Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    DM Cowley, BC McWhinney, JM Brown, and AH Chalmers, Chemical factors important to calcium nephrolithiasis; evidence of impaired hydroxy-carboxylic acid absorption causing hyperoxaluria, Clin. Chim. 33: 243 (1987).Google Scholar
  2. 2.
    BC McWhinney, SL Nagel, DM Cowley, JM Brown, and AH Chalmers, Two-carbon oxalogenesis compared in recurrent calcium oxalate stone formers and normal subjects, Clin. Chim. 33: 1118 (1987).Google Scholar
  3. 3.
    AH Chalmers, DM Cowley, and JM Brown, A possible etiological role for ascorbate in calculi formation, Clin. Chim. 32: 333 (1986).Google Scholar
  4. 4.
    JM Brown, G Stratman, DM Cowley, BM Mottram, and AH Chalmers, The variability and dietary dependence of urinary oxalate excretion in recurrent calcium stone formers, Ann. Clin. Bioehem. 24: 385 (1987).Google Scholar
  5. 5.
    J Shuster, B Finlayson, RL Schaeffer, R Sierankowski, J Zoltek, and S Dzegede, Primary liquid intake and urinary stone disease, J. Chron. Disease. 38: 907 (1985).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • D. M. Cowley
    • 1
  • J. M. Brown
    • 1
  • B. C. McWhinney
    • 1
  • A. H. Chalmers
    • 1
  1. 1.Departments of Pathology and MedicineMater Misericordiae Public HospitalsSouth BrisbaneAustralia

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