Urolithiasis pp 429-430 | Cite as

Effect of Oxalate on Kidney Mitochondrial Function

  • M. Menon
  • T. Strzelecki
  • B. McGraw
  • C. Scheid

Abstract

We have previously shown that oxalate is transported into mitochondria by the dicarboxylate carrier (1). Since we had postulated that mitochondrial dysfunction contributes to renal stone formation, we predicted that oxalate would affect mitochondrial function in kidney cells to a greater extent than in the liver since calcium-oxalate stones occur only in the kidney. This prediction was examined by comparing the effects of oxalate on two distinct mitochondrial processes - dicarboxylate transport and respiration - in both liver and kidney cortical mitochondria.

Keywords

Calcium Uptake Liver Mitochondrion Mitochondrial Calcium Oxalate Concentration Kidney Mitochondrion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    T Strzelecki and M Menon, The uptake of oxalate by rat liver and kidney mitochondria, J. Biol. Chem. 261: 1219 (1986).Google Scholar
  2. 2.
    RE Hautmann, Intra-renal calcium and oxalate concentration gradients, in: “Oxalate in Human Biochemistry and Clinical Pathology”, GA Rose, WG Robertson, and RWE Watts, eds., The Wellcome Foundation, Ltd., London (1979).Google Scholar
  3. 3.
    A Scarpa, Measurements of cation transport with metallochrome indicators, Methods Enzymology 56: 301 (1979).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. Menon
    • 1
  • T. Strzelecki
    • 1
  • B. McGraw
    • 1
  • C. Scheid
    • 1
  1. 1.University of Massachusetts Medical CenterWorcesterUSA

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