Urolithiasis pp 421-423 | Cite as

Oxalate Synthesizing Enzymes in Rat Liver

  • M. Yanagawa
  • E. Maeda-Nakai
  • A. Ichiyama
  • K. Yamakawa
  • I. Yamamoto
  • J. Kawamura
  • S. Tada

Abstract

Glyoxylate is believed to be the immediate precursor of oxalate, and three enzymes, lactate dehydrogenase (LDH), xanthine oxidase (XOD), and glycolate oxidase (GOD) have been known to catalyze the oxidation of glyoxylate to oxalate. In 1979, Fry and Richardson (1) purified an enzyme from human liver which oxidizes glycolate to oxalate without forming glyoxylate as a free intermediate. They named the enzyme “glycolate dehydrogenase (GDH)”. However, which of the four enzymes is mainly responsible for the production of oxalate still remains to be elucidated.

Keywords

Xanthine Oxidase Ammonium Sulfate Glycolic Acid Oxalate Oxidase Oxalate Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    DW Fry and KE Richardson, Isolation and characterization of glycolic acid dehydrogenase from human liver, Biochim. Biophys. Acta 567: 482 (1979).PubMedCrossRefGoogle Scholar
  2. 2.
    A Ichiyama, E Nakai, T Funai, T Oda, and R Katafuchi, Spectrophotometric determination of oxalate in urine and plasma with oxalate oxidase, J. Biochem. 98: 1375 (1985).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. Yanagawa
    • 1
  • E. Maeda-Nakai
    • 2
  • A. Ichiyama
    • 2
  • K. Yamakawa
    • 1
  • I. Yamamoto
    • 1
  • J. Kawamura
    • 1
  • S. Tada
    • 1
  1. 1.Department of UrologyMie University School of MedicineTsuJapan
  2. 2.Department of BiochemistryHamamatsu University School of MedicineHamamatsuJapan

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