Premature Infants Treated with Furosemide have Increased Urinary Calcium and Unchanged Urinary Citrate Excretion Compared to Controls
Nephrocalcinosis (NC) is a frequent complication in very low birth weight (VLBW, <1500 g) infants who are treated with furosemide (F) for bronchopulmonary dysplasia (BPD). Since most infants treated with F become hypercalciuric, yet only half develop NC, factors other than calcium excretion must contribute to the development of this disorder. We postulate that citrate excretion which appears to be under developmental control, may be one of these factors.
KeywordsPremature Infant Calcium Oxalate Bronchopulmonary Dysplasia Renal Tubular Acidosis Ethacrynic Acid
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