Urolithiasis pp 363-366 | Cite as

Prostaglandin E2 and Hydrochlorothiazide-Mediated Hypocalciuria: A Hypothesis

  • L. Calò
  • S. Cantaro
  • F. Marchini
  • G. Gambaro
  • B. Baggio
  • A. D’Angelo
  • H. Williams
  • A. Borsatti

Abstract

Prostaglandin E2 (PGE2) appears to be an important factor in calcium handling by the kidney (1) and has been forwarded as a determinant of hypercalciuria (2, 3). Thiazide diuretics are known to lower Ca excretion, and are widely used to prevent recurrent renal stone formation (4). However, the mechanism(s) by which thiazides lower urinary Ca is unclear. The purpose of this study was to search for a possible link between thiazides and PGE2 in the control of urinary Ca excretion.

Keywords

Parathyroid Hormone Thiazide Diuretic Idiopathic Hypercalciuria Rabbit Proximal Tubule PGE2 Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • L. Calò
    • 1
  • S. Cantaro
    • 1
  • F. Marchini
    • 1
  • G. Gambaro
    • 1
  • B. Baggio
    • 1
  • A. D’Angelo
    • 1
  • H. Williams
    • 2
  • A. Borsatti
    • 1
  1. 1.Institute of Internal Medicine, Division of NephrologyUniversity of PadovaItaly
  2. 2.University of California School of MedicineDavisUSA

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