Hypercalciuria, defined as an elevated daily rate of urinary Ca excretion that results in a higher average prevailing urinary-Ca concentration, is one of the risk factors for Ca oxalate/apatite precipitation, stone nucleation, and stone growth. The additional Ca appearing in the urine might be the consequence of: a) defective renal-tubular reabsorption of filtered Ca with compensatory augmentation of intestinal absorption of dietary Ca and bone remodeling; b) a primary increase of intestinal Ca absorption, either dependent on or independent of 1,25(OH)2D; c) accelerated bone remodeling or increased net-bone resorption; or d) some more-generalized acceleration of Ca transport involving all of these processes. The theme poster discussion devoted to hypercalciuria in relationship to nephrolithiasis included active discussion of 11 reports of studies addressing these issues as well as the role of urinary oxalate excretion and of urinary citrate excretion.
KeywordsIdiopathic Hypercalciuria Urinary Oxalate Excretion Citrate Excretion Medullary Sponge Kidney Stone Episode
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