Total-Body Irradiation in Bone Marrow Transplantation
The exquisite sensitivity of lymphohematopoietic tissues to ionizing radiation has been known since shortly after the discovery of x rays by Roentgen. The most prominent features of the hematopoietic syndrome in experimental animals are hemorrhagic complications and susceptibility to infections. Since the late 1940’s it has been known that the hematopoietic radiation injury could be modified by subsequent infusion of bone marrow. By the mid-1950’s, three independent groups of investigators showed that the lifesaving effect of marrow infusions was due to the presence of pluripotent stem cells in the transplant, from which regrowth of the damaged hematopoietic system occurred.
KeywordsTotal Body Irradiation Hematopoietic Growth Factor Marrow Graft Hematopoietic Recovery Radiation Accident
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