The Poly(nonapeptide) of Elastin: A New Elastomeric Polypeptide Biomaterial
This paper reports the first data on a new member of the class of elastomeric polypeptide biomaterials. The new member is poly(VPGFGVGAG). The synthesis is demonstrated by carbon-13 and proton nuclear magnetic resonance spectra; the temperature ranges for the inverse temperature transition have determined by temperature profiles for turbidity formation (aggregation); and the material has been crosslinked by γ-irradiation to produce elastomeric matrices. Poly(VPGFGVGAG) is distinguished from elastomeric poly(VPGVG) and poly(VPGG) by exhibiting a greater elastic modulus for the same cross-linking treatment, some two orders of magnitude larger, and by simultaneously being chemotactic toward endothelial cells and fibroblasts. These properties appear to be particularly appropriate for consideration of this bioelastic as a scaffolding for the reconstruction of ligaments.
KeywordsBenzyl Ester Proton Nuclear Magnetic Resonance Spectrum Nuclear Overhauser Enhancement Spectroscopy Acid Benzyl Ester Viscoelastic Phase
1 ethyl-3-dimethylaminopropyl carbodiimide
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