Carbonic Anhydrase Kinetics and Molecular Function

  • Raja G. Khalifah
  • David N. Silverman

Abstract

Detailed kinetic and mechanistic studies of the zinc metalloenzyme carbonic anhydrase (CA) became possible only after the discovery of its existence in the form of two distinct though homologous erythrocyte isozymes, CA I and CA II. For a comprehensive early review of the structure and function of CA, see reference 72. Studies in the last decade have led to the discovery of the low-specific-activity CA III in skeletal muscle that has now been kinetically investigated. Other CA isozymes (IV–VII) have now also been identified102 but have not been sufficiently characterized by kinetics to cover here.

Keywords

Proton Transfer Intramolecular Proton Transfer Water Ligand Human Carbonic Anhydrase Intermolecular Proton Transfer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Raja G. Khalifah
    • 1
  • David N. Silverman
    • 2
  1. 1.Biochemistry DepartmentKansas University Medical School, and Research Service, Veterans Administration Medical CenterKansas CityUSA
  2. 2.Department of PharmacologyUniversity of Florida College of MedicineGainesvilleUSA

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