Structure and Evolutionary Origins of the Carbonic Anhydrase Multigene Family

  • David Hewett-Emmett
  • Richard E. Tashian

Abstract

The purpose of this chapter is to provide a concise and useful resource detailing our current knowledge of the organization, structure, and evolution of the carbonic anhydrase (CA) multigene family. Much has been accomplished since the last such synthesis,36 and aspects of these advances have been reviewed elsewhere in the interim.23,66,76 In 1984, there was firm structural evidence, mostly at the protein sequence level, for three distinct CA genes (CA1, CA2, and CA3)encoding the CA I, CA II, and CA III isozymes. However, compelling evidence existed that membrane-bound CA from kidney brush border and lung membranes47,81,83 was a distinct gene product as determined from its amino acid composition and other properties. Arguments could also be advanced that mitochondrial CA15,16,77 and the high-molecular-weight CA from ovine parotid gland24 and rat saliva22 were distinct isozymes. However, alternative splicing of mRNA or use of different promoters associated with CA I, CA II, or CA III could not be ruled out as the basis for these additional isozymes. Earlier reviews5,56,65 had raised the possibility of further tissue-specific isozymes.

Keywords

Vaccinia Virus Gene Duplication Event Pigtail Macaque Human Carbonic Anhydrase Carbonic Anhydrase Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • David Hewett-Emmett
    • 1
  • Richard E. Tashian
    • 2
  1. 1.Center for Demographics and Population Genetics, Graduate School of Biomedical SciencesThe University of Texas Health Science Center at HoustonHoustonUSA
  2. 2.Department of Human GeneticsUniversity of Michigan Medical SchoolAnn ArborUSA

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