Gastric and Jejunal Ultrastructure in Capsaicin-Treated Rats with and without Experimental Ulcer

  • Carl J. Pfeiffer
  • Stefano Evangelista
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)

Abstract

In recent years considerable interest has been demonstrated in defining the role and interactions of sensory nerves and neuropeptides in the gastrointestinal tract, where such afferent nerves are present and where some identical peptides occur in endocrine cells and neuronal tissues. Capsaicin (8-methyl-N-va-nillyl-6-nonenamide), the irritant principle of the Capsicum genus peppers, has been proven to be a valuable pharmacologic probe of high but not absolute selectivity for its actions on primary afferent neurons in the gastrointestinal tract and elsewhere (Maggi and Meli, 1988). Exogenous administration of capsaicin to animals selectively damages sensory afferents in the gut in a manner dependent upon dose, age of animal, etc. The damage occurs in gastric neurons containing tachykinins and calcitonin gene-related peptide, in substance P-containing afferents in anorectal mucosa, and other neurons. In the nervous system of the rat, somatostatin, substance P, and other neuropeptides are also depleted by systemic capsaicin desensitization (Gamse et al., 1984; Sternini and Brecha, 1985; Skofitsch and Jacobowitz, 1985).

Keywords

Gastric Mucosa Endocrine Cell Parietal Cell Chief Cell Surface Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Carl J. Pfeiffer
    • 1
  • Stefano Evangelista
    • 2
  1. 1.Department of Biomedical Sciences Virginia-Maryland Regional College of Veterinary MedicineVirginia Polytechnic Institute and State UniversityBlacksburgUSA
  2. 2.A. Menarini PharmaceuticalsPharmacology DepartmentFlorenceItaly

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