Opioid-Sensitive Peripheral Neuronal Activity in the Modulation of Gastric Mucosal Injury

  • J. V. Esplugues
  • B. J. R. Whittle
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 298)

Abstract

There is growing evidence that capsaicin-sensitive afferent neurones participate in the protective mechanisms of the gastric mucosa against damage. Animals pretreated systemically with capsaicin, at doses that lead to the ablation of capsaicin-sensitive afferent neurons, show an increase in the level of macro-scopically apparent mucosal damage in different experimental models of ulceration (Szolcsányi and Barthó, 1981; Holzer and Sametz, 1986). Furthermore, acute stimulation with capsaicin of afferent nerve endings located in the gastric mucosa protects against different ulcerogenic mechanisms (Szolcsányi and Barthó, 1981; Holzer and Lippe, 1988; Holzer et al., 1989).

Keywords

Gastric Mucosa Mucosal Damage Gastric Damage Gastric Mucosal Injury Gastric Mucosal Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Barthó, L., and Szolcsányi, J., 1981, Opiate agonists inhibit neurogenic plasma extravasation in the rat, Eur. J. Pharmacol., 73:101.PubMedCrossRefGoogle Scholar
  2. Bentley, G.A., Newton, S.H., and Starr, J., 1981, Evidence for an action of morphine and the enkephalins on sensory nerve endings in the mouse peritoneum, Br. J. Pharmacol., 73:325.PubMedCrossRefGoogle Scholar
  3. Brodin, E., Gazelius, B., Panopoulos, P., and Olgart, L., 1983, Morphine inhibits substance P release from peripheral sensory nerve endings, Acta Physiol. Scand., 117:567.PubMedCrossRefGoogle Scholar
  4. Esplugues, J.V., and Whittle, B.J.R., 1988, Gastric mucosal damage by local intra-arterial administration of Paf in the rat, Br. J. Pharmacol., 93:222.PubMedCrossRefGoogle Scholar
  5. Esplugues, J.V., and Whittle, B.J.R., 1989a, Gastric effects of Paf, Meth. Find. Exp. Clin. Pharmacol., 11(Suppl.1): 61.Google Scholar
  6. Esplugues, J.V., and Whittle, B.J.R., 1989b, Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats, Am. J. Physiol., 256:G275.Google Scholar
  7. Esplugues, J.V., Whittle, B.J.R., and Moncada, S., 1989, Local opioid-sensitive afferent sensory neurones in the modulation of gastric damage induced by Paf, Br. J. Pharmacol., 97:579.PubMedCrossRefGoogle Scholar
  8. Esplugues, J.V., and Whittle, B.J.R., 1990, Morphine potentiation of ethanol-induced gastric mucosal damage in the rat: Role of local sensory afferent neurons, Gastroenterology, 98:82.PubMedGoogle Scholar
  9. Ferreira, S.H., and Nakamura, M., 1979, II-Prostaglandin hyperalgesia. The peripheral analgesic activity of morphine, enkephalins and opioid antagonists, Prostaglandins, 18:191.PubMedCrossRefGoogle Scholar
  10. Gamse, R., and Saria, A., 1987, Antidromic vasodilatation in the rat hindpaw measured by laser Doppler flowmetry: pharmacological modulation, J. Auton. Nerv. Syst., 19:105.PubMedCrossRefGoogle Scholar
  11. Gyires, K., Fürst, S., Farczadi, E., and Marton, A., 1985, Morphine potentiates the gastroulcerogenic effect of indomethacin, Pharmacology, 30:25.PubMedCrossRefGoogle Scholar
  12. Holzer, P., and Sametz, W., 1986, Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons, Gastroenterology, 91:97.Google Scholar
  13. Holzer, P., and Lippe, I. Th., 1988, Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of the gastric mucosa, Neuroscience, 27:981.PubMedCrossRefGoogle Scholar
  14. Holzer, P., Pabst, M.A., and Lippe, I. Th., 1989, Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa, Gastroenterology, 96:1425.PubMedGoogle Scholar
  15. Kao, C.Y., 1966, Tetrodotoxin, saxitonin and their significance in the study of excitation phenomena, Pharmacol. Rev., 18:997.PubMedGoogle Scholar
  16. Konishi, S., Tsunoo, A., Yanaihara, N., and Otsuka, M., 1980, Peptidergic excitatory and inhibitory synapses in mammalian sympathetic ganglia: roles of substance P and enkephalin, Biomed. Res., 1:528.Google Scholar
  17. Lembeck, F., and Donnerer, J., 1985, Opioid control of the function of primary afferent substance P fibres, Eur. J. Pharmacol., 114:241.PubMedCrossRefGoogle Scholar
  18. Pique, J.M., Esplugues, J.V., and Whittle, B.J.R., 1990, Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF, Am. J. Physiol., in press.Google Scholar
  19. Rosam, A.C., Wallace, J.L., and Whittle, B.J.R., 1986, Potent ulcerogenic actions of platelet-activating factor on the stomach, Nature, 319:54.PubMedCrossRefGoogle Scholar
  20. Russell, N.J.W., Schaible, H.-G., and Schmidt, R.F., 1987, Opiates inhibit the discharges of fine afferent units from inflamed knee joint of the cat, Neurosci. Lett., 76:107.PubMedCrossRefGoogle Scholar
  21. Selye, M., 1935, A syndrome produced by diverse nocuous agents, Nature, 138:32.CrossRefGoogle Scholar
  22. Smith, T.W., Buchan, P., Parsons, D.N., and Wilkinson, S., 1982, Peripheral antinoceptive effects of N-methylmorphine, Life Sci., 31:1205.PubMedCrossRefGoogle Scholar
  23. Szolcsányi, J., and Barthó, L., 1981, Impaired defense mechanisms to peptic ulcer in the capsaicin-desensitized rat, in: “Gastrointestinal Defense Mechanisms”, Gy. Mozsik, O. Hanninen, and T. Javor, eds., Pergamon Press and Akademiai Kiado, Oxford and Budapest.Google Scholar
  24. Till, M., Gati, T., Rabai, K., Szombath, D., and Szekeley, J.I., 1988, Effect of [D-Met2-Pro5] enkephalinamide on gastric ulceration and transmucosal potential difference, Eur. J. Pharmacol., 150:3 25.CrossRefGoogle Scholar
  25. Whittle, B.J.R., Morishita, T., Ohya, Y., Leung, F.W., and Guth, P.H., 1986, Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa, Am. J. Physiol., 251:G77.Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • J. V. Esplugues
    • 1
  • B. J. R. Whittle
    • 2
  1. 1.Departments of PharmacologyUniversity of ValenciaSpain
  2. 2.Wellcome Research LaboratoriesBeckenham, KentUK

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