Complexes of Peptides and Related Molecules with Diammineplatinum (II) as Models for Platinum-Protein Interactions
To the extent that the platinum compounds react with such molecules, they are prevented from reacting with the target DNA.
Some of the toxic side-effects of platinum drugs are due to platinum-protein interactions.
Some forms of resistance of tumor cells toward platinum drugs may be due to enhanced coordination by peptides and proteins.
KeywordsNuclear Magnetic Resonance Imidazole Ring Chelate Ring Platinum Complex Platinum Compound
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