Phase I Trials with Ormaplatin (Tetraplatin)
Interest in compounds with the 1,2-diaminocyclohexane (DACH) carrier ligand was stimulated by the observation by Burchenal, et al. (1) that platinum compounds containing this structure retained activity against L1210 leukemia cells with acquired resistance to cisplatin (CDDP). In addition to an improved therapeutic index through toxicity reduction or modification or greater antitumor activity, the identification of non-cross-resistant compounds is a major goal of platinum analog development. 4’carboxyphthalato(1,2 diaminocyclohexane) Platinum (II), one of few DACH compounds to receive a clinical evaluation, entered clinical trials briefly several years ago. However, its solubility was limited making it unsuitable for large scale clinical trials (2). Few tumor types were studied adequately and the question of the clinical non-cross-resistance of the DACH-Pt compounds remains to be answered.
KeywordsHuman Ovarian Cancer Cell Line L1210 Leukemia Cell Muscle Tremor Small Cell Lung Carcinoma Cell Routine Blood Count
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