Multiple Cyclooxygenases: Cloning of a Mitogen-Inducible Form

  • Daniel L. Simmons
  • Weilin Xie
  • Jeffrey G. Chipman
  • Gary E. Evett
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Cyclooxygenase (prostaglandin G/H synthase, E.C. 1.14.99.1, abbreviated hereafter as PGHS) is a bifunctional, membrane-bound hemeprotein which catalyzes the oxygenation and endoperoxide reduction reactions required for the synthesis of prostaglandins and thromboxanes from arachidonic acid. This dimeric enzyme consists of two very similar, if not identical, 70–72 kilodalton subunits which are anchored in the lipid bilayer of the endoplasmic reticulum and other cellular membranes. The structure of the enzyme within biological membranes is unknown, although models based on the amino acid sequence have been proposed (1–3).

Keywords

Prostaglandin Synthesis Heme Binding Human Umbilical Vascular Endothelial Cell LA24 Cell Guanidinium Isothiocyanate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Daniel L. Simmons
    • 1
  • Weilin Xie
    • 1
  • Jeffrey G. Chipman
    • 1
  • Gary E. Evett
    • 1
  1. 1.Department of ChemistryBrigham Young UniversityProvoUSA

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