Thromboxane A2/Prostaglandin H2 Receptors: A Growing Family of Receptor Subtypes

  • Perry V. Halushka
  • Thomas A. Morinelli
  • Atsushi Masuda
  • Dale E. Mais
Chapter
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

The presence of TXA2/PGH2 receptors on platelets, blood vessels and vascular smooth muscle has been established using both pharmacologic (1–2,5) and radioligand binding studies (3,6). However, debate exists as to whether or not platelet and vascular TXA2/PGH2 receptors are different. Pharmacological studies using human platelets and blood vessels from different species supported the notion that they were different (7, 8). However, since these studies crossed species and often used only a single compound, the possibility of species difference versus true receptor heterogeneity remained uncertain. Mais et al. (8–10) using analogues of 13-azapinane TXA2 provided pharmacological evidence that in the human and dog, the platelet and vascular TXA2/PGH2 receptors were different. Morinelli et al. (11) also provided pharmacological evidence that platelet and vascular receptors were different, using analogues of 10,10 difluoro TXA2. However, other pharmacologic and radioligand binding studies have failed to find differences between the platelet and vascular receptors even when crossing species (12–14). Thus, it remains controversial whether platelet and vascular TXA2/PGH2 receptors are different.

Keywords

Human Platelet Radioligand Binding Radioligand Binding Study Platelet Thromboxane Washed Human Platelet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Perry V. Halushka
    • 1
    • 2
  • Thomas A. Morinelli
    • 1
    • 2
  • Atsushi Masuda
    • 1
    • 2
  • Dale E. Mais
    • 1
    • 2
  1. 1.Medical University of South CarolinaCharlestonUSA
  2. 2.Eli Lilly Pharmaceutical CompanyIndianapolisUSA

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