The Study on the Formulation of a Tc(V)-99m-DMS Lyophilized Instant Kit for Tumor Scintigraphy

  • Shiaw-Pyng Wey
  • Lie-Hang Shen
  • Gann Ting
  • Shiang-Bin Jong
  • Chung-Chieng Wu

Abstract

The Tc(V)-99m Dimercaptosuccinate (DMS) as a tumor seeking agent has been studied by several laboratories. The published preparation methods were either in situ complexation or two step constitution of commercial renal imaging kit. A new formulation of lyophilized instant kit for one step preparation of Tc(V)-99m DMS complex has been developed in this study. High labeling yield (over 95%) and good shelf stability of the kit were obtained in our laboratory by investigating the formulation of Tc-99m complexes with radio-TLC, electrophoresis and HPLC methods. The results of clinical trial showed the superiority of scintigraphy for diagnosis of bone tumors, soft-tissue tumors and their malignant metastases.

Keywords

High Performance Liquid Chromatography Stannous Chloride High Performance Liquid Chromatography Method Dimercaptosuccinic Acid Radioactive Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Shiaw-Pyng Wey
    • 1
  • Lie-Hang Shen
    • 1
  • Gann Ting
    • 1
  • Shiang-Bin Jong
    • 2
  • Chung-Chieng Wu
    • 2
  1. 1.Isotope Applications DivisionInstitute of Nuclear Energy ResearchLung-Tan, TaiwanROC
  2. 2.Department of Nuclear MedicineKaohsiung Medical College HospitalKaohsiung, TaiwanROC

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