Methadone and Related 3,3-Diphenylpropylamines

  • Alan F. Casy
  • Robert T. Parfitt

Abstract

During World War II, chemists working in the Hoechst Laboratories of I. G. Farbenindustrie discovered that certain derivatives of 3,3-diphenyl-N,N-dimethylpropylamine had analgesic properties. Details of this work, acquired by the Allies as one of the fruits of victory,(1) provided a lead to a novel class of analgesic that was followed with vigor on both sides of the Atlantic. The best-known member of the group is 6-dimethylamino-4,4-diphenylheptan-3-one (1, methadone, amidone, Physeptone), which was introduced into clinical practice in 1946; several variants obtained by modifying the basic group and/or ketone function have also been marketed as analgesics.

Keywords

Chiral Center Potency Ratio Related Analgesic Erythro Isomer Racemic Methadone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Alan F. Casy
    • 1
  • Robert T. Parfitt
    • 1
    • 2
  1. 1.University of BathBathUK
  2. 2.Canberra College of Advanced EducationBelconnenAustralia

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