Hormonal Modulation of the Human Autologous Mixed Lymphocyte Reaction

  • Georges J. M. Maestroni

Abstract

“Mens sana in corpore sano”. This roman proverb expresses beautifully the ancient recognition of the organism unity and it implies awareness of mutual influences between mind and body. As a consequence, it should not be surprising to find, in our analytical era, specific connections between the major homestatic device of the mind — the neuroendocrine system- and the major homestatic device of the body — the immune system. In fact, several years details of these connections are increasingly piled to give a complicated and still confusing picture. A rather exhaustive review of our knowledge of the field may be found in the recently published book “Psychoneuroimmunology” (R. Ader, ed., 1981). Most recently however, the field of neuroimmunomodulation has become fashionable and the list of neurohormones known to have important immunomodulatory properties has increased (Johnson et al., 1982; Mathews et al., 1983; Plotnikoff and Miller, 1983; Miller et al., 1984; Faith et al and Murgo et al., 1984). On the other hand, the already proposed view of lymphocytes producing messengers for the neuroendocrine system (Pierpaoli and Maestroni, 1977; Maestroni and Pierpaoli, 1981) has been further confirmed and detailed (Smith and Blalock, 1981; Smith et al., 1983). The mechanisms by which both the neuroendocrine and the immune system synergizes in order to preserve the organism from environment challenges are thus becoming slowly clearer. The so called psychosomatic integrity appears as a finely tuned balance of neuroendocrine and immune interactions. It becomes also more conceivable that a deranged or exaggerated psychoneuroendocrine response to environmental stimuli or a continuous exposure to stress events may lead to pathological alterations of the immune system.

Keywords

Systemic Lupus Erythematosis ATPase Activity Thyroid Stimulate Hormone Pokeweed Mitogen Rheumatoid Arth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ahlqvist, J., 1981, Hormonal influences on immunologic and related phenomena, in: “Psychoneuroimmunology,” R. Ader, ed., Academic Press, New York.Google Scholar
  2. Blomgren, H., 1974, Steroid sensitivity of the response of human lymphocytes to phytohemagglutinin and pokeweed mitogen: role of phagocytic cells, Scand. J. Immunol., 3: 655.Google Scholar
  3. Breslow, E., 1984, Neurophysin: biology and chemistry of its interactions, in: “Cell biology of the secretory process,” M. Cantin, ed., S. Karger, Basel.Google Scholar
  4. Chen, P. S., Toribara, T. Y., and Warner, H., 1956, Microdetermination of phosphorus, Anal. Chem., 28: 1756.Google Scholar
  5. Danel, L., Souweine, G., Monier, J.C., and Saez, S., 1983, Specific estrogen binding sites in human lymphoid cells and thymic cells, J. Steroid Biochem., 18: 559.PubMedCrossRefGoogle Scholar
  6. DeCoursey, T. E., Chandy, K. G., Gupta, S., and Cahalan, M. D., 1984, Voltagegated K channels in human T lymphocytes: a role in mitogenesis ?, Nature, 307: 465.PubMedCrossRefGoogle Scholar
  7. Dubois, E. L., 1974, The clinical picture of systemic lupus erythematosus, in: “Lupus erythematosus,” 2nd edition, E. L. Dubois, ed., University of Southern California Press, Los Angeles.Google Scholar
  8. Feldman, S. P., Mertelsman, R., Venuta, S., Andreed, M., Welte, K., and Moore, A. S. M., 1983, Sodium azide enhancement of interleukin-2 production, Blood, 61: 815.PubMedGoogle Scholar
  9. Frankenhauser, M., Rauste-von Wright, M., Collins, A., von Wright, J., Sedvall, G., and Swahn, C. G., 1978, Sex differences in psychoneuroendocrine reactions to examination stress, Psychosom. Med., 40: 334.Google Scholar
  10. Gutierrez, C., Bernabe, R. R., Vega, J., and Kreisler, M., 1979, Purification of human T and B cells by a discontinuous density gradient of percoll, J. Immunol. Meth., 29: 57.Google Scholar
  11. Herr, H. W., 1982, Effect of estrogen on the mixed lymphocyte reaction in normal individuals and prostatic cancer patients, The Prostate, 3: 17.PubMedCrossRefGoogle Scholar
  12. Ilfeld, D. N., Krakauer, R. S., and Blaese, M. R., 1977, Suppression of the human autologous mixed lymphocyte reaction by physiologic concentrations of hydrocortisone, J. Immunol., 119: 428.PubMedGoogle Scholar
  13. Johnson, H. M., Smith, E. M., Torres, B. A., and Blalock, J. E., 1982, Regulation of the in vitro antibody response by neuroendocrine hormones, Proc. Natl. Acad. Sci. U.S.A., 79: 4171.Google Scholar
  14. Katz, P., and Fauci, A. S., 1979, Autologous and allogeneic intercellular interactions: modulation by adherent cells, irradiation, and in vitro and in vivo corticosteroids, J. Immunol., 123: 2270.PubMedGoogle Scholar
  15. Kobayashi, H., Maeda, M., and Anraku, Y., 1977, Membrane-bound adenosine triphosphatase of Echerichia Coli. IV effect of sodium azide on the enzyme functions, J. Biochem., 81: 1071.Google Scholar
  16. Kotani, H., Takada, S., Ueda, Y., Murakawa, Y., Suzuki, N., and Sakane, T., 1984, Activation of immunoregulatory circuits among OKT4+ cells by autologous mixed lymphocyte reactions, Clin. Exp. Immunol., 56: 390.Google Scholar
  17. Lahita, R. G., Bradlow, H. L., Kunkel, H. G., and Fishman, J., 1979Google Scholar
  18. Alterations of estrogen metabolism in systemic lupus erythematosus, Arthritis Rheum., 22:1195.Google Scholar
  19. Losa, G., Morell, A., Barandun, S., 1982, Correlations between enzymatic and immunologic properties of human peripheral blood mononuclear cells, Am. J. Pathol., 107: 191.Google Scholar
  20. Maestroni, G. J. M., and Pierpaoli, W., 1981, Pharmacological control of the hormonally mediated immune response, in: “Psychoneuroimmunology,” Ader, ed., Academic Press, New York.Google Scholar
  21. Mathews, P. M., Froelich, G. J., Sibbit, W. L., and Bankhurst, D., 1983, Enhancement of natural cytotoxicity by p-endorphin, J. Immunol., 130: 1658.PubMedGoogle Scholar
  22. Mendelsohn, J., Multer, M. M., and Bernheim, J. L., 1977, Inhibition of human lymphocyte stimulation by steroid hormones: cytokinetic mechanisms, Clin. Exp. Immunol., 27: 127.Google Scholar
  23. Miller, R. A., and Kaplan, H. S., 1978, Generation of cytotoxic lymphocytes in the autologous mixed lymphocyte culture, J. Immunol., 121: 2165.PubMedGoogle Scholar
  24. Miller, G. C., Murgo, A. J., and Plotnikoff, N. P., 1984, EnkephalinsEnhancement of active T-cells rosettes from normal volunteers, Clin. Immunol. Immunopath., 31: 132.Google Scholar
  25. Opelz, G., Kiuchi, M., Takasugi, M., and Terasaki, P. I., 1975, Autologous stimulation of human lymphocytes subpopulations, J. Exp. Med., 142: 1327Google Scholar
  26. Persellin, R. H., 1977, The effect of pregnancy on rheumatoid arthritis, Bull. Rheum. Dis., 27: 922.Google Scholar
  27. Pierpaoli, W., and Maestroni, G. J. M., 1977, Pharmacological control of the immune response by blockade of the early hormonal changes following antigen injection, Cell. Immunol., 31: 355.Google Scholar
  28. Plotnikoff, N. P., and Miller, G. C., 1983, Enkephalins as immunomodulators, Int. J. Immunopharmac., 5:437. “Psychoneuroimmunology,” 1981, R. Ader, ed., Academic Press, New York.Google Scholar
  29. Robinson, A. G., Archer, D. F., and Tolstoi, L. F., 1973, Neurophysin in women during oxytocin-related events, J. Clin. Endocrinol. Met., 37: 645.Google Scholar
  30. Robinson, A. G., 1974, Elevation of plasma neurophysin in women on oral contraceptives, J. Clin. Invest., 54: 209.Google Scholar
  31. Robinson, A. G., 1978a, Neurophysins, an aid to understanding the structure and function of the neurohypophysis, in: “Frontiers in Neuroendocrinology,” Vol. 5, W. F. Ganong and L. Martini, eds., Raven Press, New York.Google Scholar
  32. Robinson, A. G., 1978b, Neurophysins, in: “Clinical Neuroendocrinology,” L. Martini, and G. M. Besser, eds., Academic Press, New York.Google Scholar
  33. Schlesinger, M., and Chaovat, M., 1972, Modulation of the H-2 antigenicity on the surface of murine peritoneal cells, Tissue Antigens, 2: 427.PubMedCrossRefGoogle Scholar
  34. Smith, J. B., and Knowlton, R. P., 1979, Activation of suppressor T cells in human autologous mixed-lymphocyte culture, J. Immunol., 123: 419.PubMedGoogle Scholar
  35. Smith, E. M., and Blalock, J. E., 1981, Human Lymphocyte production of ACTH and endorphin-like substances: association with leukocytes interferon, Proc. Natl. Acad. Sci. U.S.A., 78: 7530.Google Scholar
  36. Smith, J. B., and DeHoratius, R. J., 1982, Deficient autologous mixed lymphocyte reactions correlate with disease activity in systemic lupus erythematosus and rheumatoid arthritis, Clin. Exp. Immunol., 48: 155.Google Scholar
  37. Smith, E. M., Phan, M., Coppenhaver, D., Kruger, T. E., and Blalock, J. E., 1983, Human lymphocyte production. of immunoreactive thyrotropin, Proc. Natl. Acad. Sci. U.S.A., 80: 6010.Google Scholar
  38. Smolen, J. S., Sharrow, S. O., Roeves, J. P.., Boegel, W. A., and Steinberg, A. D., 1981, The human autologous mixed lymphocyte reaction I suppression by macrophages and T cells, J. Immunol., 127: 1987.Google Scholar
  39. Solomon, G. F., 1981, Emotional and personality factors in the onset and course of autoimmune disease, particularly rheumatoid arthritis, in: “Psychoneuroimmunology,” R. Ader, ed., Academic Press, New York.Google Scholar
  40. Solomon, G. F., and Amkraut, A. A., 1981, Psychoneuroimmunological effects on the immune response, Ann. Rev. Microbiol., 35: 155.Google Scholar
  41. Stackpole, C. W., Jacobson, J. B., and Smith, M. P., 1978, Two distinct types of capping of surface receptors on mouse lymphoid cells, Nature, 248: 232.CrossRefGoogle Scholar
  42. Steinberg, A. D., Melez, K. A., Raveche, E. S., Reeves, J. P., Boegel, W. A., Smathers, P. A., Taurog, J. D., Weinlein, L., and Duvic, M., 1979, Approach to the study of the role of sex hormones in autoimmunity, Arthritis Rheum., 22: 1170.PubMedCrossRefGoogle Scholar
  43. Stoeck, M., Northoff, H., and Resh, K., 1983, Inhibition of mitogen-induced lymphocyte proliferation by ouabain interference with interleukin-2 production and interleukin-2 action, J. Immunol., 131: 1433.PubMedGoogle Scholar
  44. Theophilopoulos, A. N., and Dixon, F. J., 1982, Autoimmune diseases. Immunopathology and etiopathogenesis, Am. J. Pathol., 108: 321.Google Scholar
  45. Vandenbroucke, J. P., Valkenburg, H. A., Boersma, J. W., Cats, A., Festen, J. J. M., Huber-Bruning, O., and Rasker, J. J., 1982, Oral contraceptives and rheumatoid arthritis; further evidence for a preventive effect, The Lancet, ii: 839.Google Scholar
  46. Weksler, M. E., Moody, Jr. C. E., and Kozak, R. W., 1981, The autologous mixed-lymphocyte reaction, Adv. Immunol., 31: 271.Google Scholar
  47. Wyle, F. A., and Kent, J. R., 1977. Immunosuppression by sex steroid hormones I the effect upon PHA- and PPD-stimulated lymphocytes, Clin. Exp. Immunol., 27: 407.Google Scholar
  48. Yocum, M.W., Grossman, J., Waterhouse, C., Abraham, G. N., May, A. G., and Condemi, J. J., 1975, Monozygotic twins discordant for systemic lupus erythematosus, Arthritis Rheum., 18: 193.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Georges J. M. Maestroni
    • 1
  1. 1.Laboratory of Cellular PathologyIstituto cantonale di patologiaLocarnoSwitzerland

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