Phospholipid-Protein Kinase C Involvement in the Adrenergic Regulation of Pinealocyte Cyclic AMP: A Model of How Modulators Act?

  • David C. Klein
  • David Sugden
  • Jiri Vanecek
  • Thomas P. Thomas
  • Wayne B. Anderson
Conference paper
Part of the FIDIA Research Series book series (FIDIA, volume 4)

Abstract

The mammalian pineal gland is regulated by norepinephrine (NE) released into the pineal perivascular space from sympathetic nerve terminals; there is a 24-hour pattern of release, with high levels occurring at night. This rhythmic release of NE is controlled by a neural circuit which includes a circadian clock and passes through both central and peripheral structures (Klein et al., 1981).

Keywords

Adenylate Cyclase Pineal Gland Sympathetic Nerve Terminal Adrenergic Regulation Stimulate Guanylate Cyclase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • David C. Klein
    • 1
  • David Sugden
    • 1
  • Jiri Vanecek
    • 1
    • 2
  • Thomas P. Thomas
    • 1
    • 3
  • Wayne B. Anderson
    • 1
    • 3
  1. 1.Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaUSA
  2. 2.Institute of PhysiologyCzechoslovak Academy of SciencesPragueCzechoslovakia
  3. 3.Laboratory of Tumor Immunology and BiologyNational Cancer InstituteBethesdaUSA

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