Phospholipid-Protein Kinase C Involvement in the Adrenergic Regulation of Pinealocyte Cyclic AMP: A Model of How Modulators Act?
The mammalian pineal gland is regulated by norepinephrine (NE) released into the pineal perivascular space from sympathetic nerve terminals; there is a 24-hour pattern of release, with high levels occurring at night. This rhythmic release of NE is controlled by a neural circuit which includes a circadian clock and passes through both central and peripheral structures (Klein et al., 1981).
KeywordsAdenylate Cyclase Pineal Gland Sympathetic Nerve Terminal Adrenergic Regulation Stimulate Guanylate Cyclase
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- Klein DC, Auerbach DA, Namboodiri MAA, Wheler GHT (1981) Indole amine metabolism in the mammalian pineal gland. In: Reiter RJ (ed): The Pineal Gland: Anatomy and Biochemistry. CRC Press, Boca Raton, Florida pp. 199–227.Google Scholar