Syndrome of Inappropriate Antidiuretic Hormone Secretion and Hyponatremia
Hyponatremia, defined as a plasma sodium concentration of less than 135 meq/dl, may be seen in as many as 25% of all hospitalized patients.1 In the cancer patient without overt cardiac or liver failure, hyponatremia may be present as a chronic asymptomatic condition.2–8 However, it is important to note that the level of hyponatremia that can cause signs or symptoms varies with the rate of decline of plasma sodium concentration as well as the age of the patient.
KeywordsChronic Obstructive Pulmonary Disease Pituitary Adenoma Plasma Osmolality Nephrogenic Diabetes Insipidus Serum Sodium Concentration
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- 8.Greco AF, et al: Hormone production and paraneoplastic syndromes, In: Greco AF, Oldham RK, Bunn PA, Jr (eds.): Small Cell Lung Cancer, Clinical Oncology Monograph, p. 177. New York, Grune and Stratton, 1981.Google Scholar