The Effect of Taurine on Excitatory Receptor Binding in Rat Hippocampal Membranes

  • F. Bennardini
  • P. Failli
  • R. Matucci
  • A. Bartolini
  • D. Morandini
  • L. Polenzani
  • F. Franconi
  • A. Giotti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)

Abstract

Recent reports have shown that L-3H glutamate binds with high affinity to hippocampal membranes (12). Moreover, this binding is increased by CaCl2 (1), although it is still under discussion whether the calcium increase is mediated by chloride ions (11,16). Many authors suggest that Ca2+ can activate neutral protease (2) and that the activity of these proteases could be responsible for learning and memory capability (10). Taurine is a molecule that is able to reduce L-glutamate-induced depolarization in isolated frog spinal cord (7) and to abolish the after-hyperpolarization induced by L-glutamate (8). Moreover, it reduces acquisition of avoidance conditioned reflex (14) and decreases acquisition and, to a lesser extent, retention of a step-down passive avoidance task (13). In the nervous system, taurine interacts with calcium. In fact, 25 mM taurine increases the high affinity Ca2+ binding to rat hippocampal membranes but has no effect on low affinity Ca2+ uptake to rat brain synaptosomes (6).

Keywords

Neutral Protease Scatchard Analysis Cold Distil Water Preincubation Period Frog Spinal Cord 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • F. Bennardini
    • 1
  • P. Failli
    • 1
  • R. Matucci
    • 1
  • A. Bartolini
    • 1
  • D. Morandini
    • 1
  • L. Polenzani
    • 1
  • F. Franconi
    • 1
    • 2
  • A. Giotti
    • 1
  1. 1.Dipartimento di Farmacologia Preclinica e Clinica, “Mario Aiazzi Mancini”Universita degli Studi di FirenzeFirenzeItaly
  2. 2.Cattedra di Saggi e Dosaggi FarmacologiciUniversità di SassariSassariItaly

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