Potentiation of Myocardial Ischemic Injury by Drug-Induced Taurine Depletion

  • S. W. Schaffer
  • S. Allo
  • M. Mozaffari
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 217)

Abstract

The discovery that taurine treatment reverses arrhythmias associated with epinephrine- and digoxin-induced toxicity stimulated research into the myocardial actions of taurine and eventually led to the hypothesis that taurine must have an important physiological function in the heart (10,14, 25,28). Two subsequent lines of evidence have provided the most compelling support for this hypothesis. First, cardiac taurine levels are extremely high and are maintained by an energy-dependent transport process (14,29). Second, exposure of the heart to a medium containing taurine results in a significant change in myocardial energy and calcium metabolism (5–7,15, 18,20,28).

Keywords

Taurine Level Taurine Transport Taurine Content Myocardial Ischemic Injury Taurine Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • S. W. Schaffer
    • 1
  • S. Allo
    • 1
  • M. Mozaffari
    • 1
  1. 1.Department of PharmacologyUniversity of South Alabama, School of MedicineMobileUSA

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