Cytotoxic Lymphocyte Killing Enters the Ice Age

  • Seamus J. Martin
  • Gustavo P. Amarante-Mendes
  • Douglas R. Green
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 406)

Abstract

Apoptosis, a mode of cell death that culminates in early recognition (i.e. before membrane rupture) of dying cells by phagocytes, appears to have been highly conserved throughout evolution. Apoptosis can be triggered by a diverse array of both physiological and pathological stimuli all of which seem to engage the same cellular machinery that is responsible for the destruction of the cell from within. Thus, although the proximal signalling events that can result in apoptosis can vary from one stimulus to another, it is likely that these signals all converge at some point on a common set of effector molecules which we will call ‘the executioner’.

Keywords

Cysteine Protease Adenomatous Polyposis Coli Family Protease Cell Death Machinery Apoptotic Thymocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Seamus J. Martin
    • 1
  • Gustavo P. Amarante-Mendes
    • 1
  • Douglas R. Green
    • 1
  1. 1.Division of Cellular ImmunologyLa Jolla Institute for Allergy and ImmunologyLa JollaUSA

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