Generation and Regulation of B Cell Autoreactivity Arising in the Periphery

  • Philip Kuo
  • Daniel Michael
  • Boaz Tadmor
  • Betty Diamond
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 406)

Abstract

Recent work on the role of environmental antigens in activating autoreactivity underscores a potentially confounding complication to current models of peripheral tolerance. Cross-reactive B cells that bind both autoantigen and foreign antigen are capable of mediating tissue damage, yet may be subject to positive selection as a consequence of interaction with antigen and T cell help. This discussion will review our work with cross-reactive antibodies and suggest a hypothesis to explain their generation and subsequent regulation.

Keywords

Somatic Mutation Germinal Center Keyhole Limpet Hemocyanin Foreign Antigen Cell Repertoire 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Philip Kuo
    • 1
  • Daniel Michael
    • 1
  • Boaz Tadmor
    • 1
  • Betty Diamond
    • 1
  1. 1.Albert Einstein College of MedicineBronxUSA

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