Cysteine String Proteins: Presynaptic Function and Dysfunction
The observation that is the basis of this chapter is the finding by Zinsmaier and colleagues1 that neuronal degeneration is present in organisms with mutations of the gene encoding cysteine string proteins (csps). Since there is still a very limited number of instances in which neurodegenerative disorders have been traced to alterations of single genes, it is plausible that studies of csp mutants will provide useful insights into the etiology of neurodegenerative diseases. To develop this thesis, we will review what is known about csps and then consider scenarios by which mutation of the csp gene could have neurodegenerative sequelae.
KeywordsSynaptic Vesicle Nerve Terminal Electric Organ Venom Gland Ethyl Methane Sulfonate
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- 7.J.A. Umbach, A. Mastrogiacomo, and C.B. Gundersen, Cysteine string proteins and presynaptic function, J. Physiol. (Paris) in press.Google Scholar