Cysteine String Proteins: Presynaptic Function and Dysfunction

  • Cameron B. Gundersen
  • Joy A. Umbach
  • Alessandro Mastrogiacomo
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)


The observation that is the basis of this chapter is the finding by Zinsmaier and colleagues1 that neuronal degeneration is present in organisms with mutations of the gene encoding cysteine string proteins (csps). Since there is still a very limited number of instances in which neurodegenerative disorders have been traced to alterations of single genes, it is plausible that studies of csp mutants will provide useful insights into the etiology of neurodegenerative diseases. To develop this thesis, we will review what is known about csps and then consider scenarios by which mutation of the csp gene could have neurodegenerative sequelae.


Synaptic Vesicle Nerve Terminal Electric Organ Venom Gland Ethyl Methane Sulfonate 
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  1. 1.
    K. Zinsmaier, K.K. Eberle, E. Buchner, K. Walter, and S. Benzer, Paralysis and early death in cysteine string protein mutants of Drosophila, Science, 263:977–980 (1994).PubMedCrossRefGoogle Scholar
  2. 2.
    K. Zinsmaier, A. Hofbauer, G. Heimbeck, G.O. Pflugfelder, S. Buchner, and E. Buchner, A cysteine-string protein is expressed in retina and brain of Drosophila, J. Neurogenet. 7:15–29 (1990).PubMedCrossRefGoogle Scholar
  3. 3.
    C.B. Gundersen and J.A. Umbach, Suppression cloning of the cDNA for a candidate subunit of a presynaptic calcium channel, Neuron, 9:527–537 (1992).PubMedCrossRefGoogle Scholar
  4. 4.
    A. Mastrogiacomo, C.J. Evans, and C.B. Gundersen, Antipeptide antibodies against a Torpedo cysteine string protein, J. Neurochenu 62:873–880 (1994).CrossRefGoogle Scholar
  5. 5.
    C.B. Gundersen, A. Mastrogiacomo, K. Faull, and J.A. Umbach, Extensive lipidation of a Torpedo cysteine string protein, J. Biol. Chem. 269:19197–19199, (1994).PubMedGoogle Scholar
  6. 6.
    A. Mastrogiacomo, S.M. Parsons, G.A. Zampighi, D.J. Jenden, J.A. Umbach, and C.B. Gundersen, Cysteine string proteins: a potential link between synaptic vesicles and presynaptic calcium channels, Science, 263:981–982 (1994).PubMedCrossRefGoogle Scholar
  7. 7.
    J.A. Umbach, A. Mastrogiacomo, and C.B. Gundersen, Cysteine string proteins and presynaptic function, J. Physiol. (Paris) in press.Google Scholar
  8. 8.
    C.B. Gundersen, A. Mastrogiacomo and J.A. Umbach, Cysteine-string proteins as templates for membrane fusion: models of synaptic vesicle exocytosis, J. Theor. Biol. 172:269–277 (1995).PubMedCrossRefGoogle Scholar
  9. 9.
    J.A. Umbach, K.E. Zinsmaier, K.K. Eberle, E. Buchner, S. Benzer, and C.B. Gundersen, Presynaptic dysfunction in Drosophila csp mutants, Neuron 13:899–907 (1994).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Cameron B. Gundersen
    • 1
  • Joy A. Umbach
    • 1
  • Alessandro Mastrogiacomo
    • 1
  1. 1.Department of Molecular & Medical PharmacologyUCLA School of MedicineLos AngelesUSA

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