Cysteine String Proteins: Presynaptic Function and Dysfunction

  • Cameron B. Gundersen
  • Joy A. Umbach
  • Alessandro Mastrogiacomo
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)

Abstract

The observation that is the basis of this chapter is the finding by Zinsmaier and colleagues1 that neuronal degeneration is present in organisms with mutations of the gene encoding cysteine string proteins (csps). Since there is still a very limited number of instances in which neurodegenerative disorders have been traced to alterations of single genes, it is plausible that studies of csp mutants will provide useful insights into the etiology of neurodegenerative diseases. To develop this thesis, we will review what is known about csps and then consider scenarios by which mutation of the csp gene could have neurodegenerative sequelae.

Keywords

Synaptic Vesicle Nerve Terminal Electric Organ Venom Gland Ethyl Methane Sulfonate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Cameron B. Gundersen
    • 1
  • Joy A. Umbach
    • 1
  • Alessandro Mastrogiacomo
    • 1
  1. 1.Department of Molecular & Medical PharmacologyUCLA School of MedicineLos AngelesUSA

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