Eicosanoids pp 111-115 | Cite as

Studies of Isoprostane Biosynthesis in Man

  • G. Ciabattoni
  • P. Patrignani
  • M. R. Panara
  • A. Greco
  • F. Cipollone
  • G. Davi
  • G. Di Minno
  • A. Coppola
  • C. Patrono
Chapter
Part of the NATO ASI Series book series (NSSA, volume 283)

Abstract

Isoprostanes represent a newly characterized family of vasoactive eicosanoids that are formed by a non-cyclooxygenase, free radical-catalyzed mechanism involving peroxidation of arachidonic acid (Morrow et al, 1990). One of these compounds is 8-epi-PGF2α which has attracted considerable attention because of its biological activity. 8-epi-PGF2α is a potent vasoconstrictor in the rat and its action is mediated, at least in part, through the vascular PGH2/TXA2 receptor (Takahashi et al., 1992). Moreover, 8-epi-PGF2α induces platelet shape change but not aggregation (Morrow et al., 1992).

Keywords

Cyclooxygenase Activity Prostaglandin Endoperoxide Silicic Acid Column Chromatography Human Blood Monocyte Chronic Cigarette Smoking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • G. Ciabattoni
    • 1
  • P. Patrignani
    • 2
  • M. R. Panara
    • 2
  • A. Greco
    • 2
  • F. Cipollone
    • 2
  • G. Davi
    • 2
  • G. Di Minno
    • 3
  • A. Coppola
    • 3
  • C. Patrono
    • 2
  1. 1.Department of PharmacologyCatholic University School of MedicineRomeItaly
  2. 2.Departments of Pharmacology and MedicineUniversity of Chieti “G. D’Annunzio” School of MedicineChietiItaly
  3. 3.Department of Internal Medicine and Metabolic DiseasesUniversity of Naples “Federico II” School of MedicineNaplesItaly

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