Ferritin

Intracellular Regulator of Metal Availability
  • J. G. Joshi

Abstract

Toxicity of cations results from excessive intake or from their presence at high concentrations in an unsequestered form. The toxic level and the expression of toxicity vary with the cation. For example, in experimental animals, exposure to Pb2+ causes, among other ill-effects, inhibition of specific enzymes involved in heme synthesis. In addition, Pb2+ causes replacement of iron in the heme by Zn2+, to generate a nonfunctional zinc protporphyrine (Jeslow, 1980). In some instances, living systems respond to toxic levels of metal ions such as Cd2+, Zn2+, or Cu2+ by synthesizing a family of proteins, metallothioneins, to sequester the detoxicant (Kojima and Kagi, 1978).

Keywords

Iron Metabolism Iron Core Ferroxidase Center Ferritin Heavy Chain Liver Ferritin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • J. G. Joshi
    • 1
  1. 1.Department of BiochemistryUniversity of TennesseeKnoxvilleUSA

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