Oxidative Stress-Induced Cell Damage in the CNS
The previous chapters in this book have reviewed the involvement of transition metals in diseases of the central nervous system. While each of the diseases described was unique in its symptoms, one common feature is present: Transition metals contribute to the pathological process by facilitating generation of reactive oxygen species (ROS). This concluding chapter will examine the cells and organelles at risk for oxidative damage and propose a final common pathway in neural pathogenesis of oxidative stress.
KeywordsNitric Oxide Amyotrophic Lateral Sclerosis Brain Mitochondrion Pyridine Nucleotide Final Common Pathway
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