Clinical Manifestations of Autosomal Recessive Early-Onset Parkinsonism with Diurnal Fluctuation

  • Yasuhiro Yamamura
  • Tatsuo Kohriyama
  • Yumiko Kaseda
  • Hideshi Kawakami
  • Sadao Katayama
  • Tsutomu Yanagi
  • Masao Uchida
  • Toshio Nakahara
  • Shigeki Kuzuhara
  • Shigenobu Nakamura
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)

Abstract

Early-onset parkinsonism includes a group of heterogeneous disorders with an onset early in life, which share clinical features with Parkinson’s disease. Among these is autosomal recessive early-onset parkinsonism with diurnal fluctuation (AR-EPDF). In 1973 we7 reported AR-EPDF, struck by the marked diurnal fluctuation of symptoms in a group of patients with early-onset parkinsonism. The disease begins in the second or third decade of age, mostly with familial trait, and presents with dystonias and marked response to antiparkinsonism drugs. Subsequent authors4, 6 have reported similar cases. Diurnal fluctuation, unrelated to drug-induced motor fluctuations, is symptomatic worsening within a few hours of waking and improvement after sleep (sleep benefit). The idea this phenomenon being characteristic of AR-EPDF lead us to compare clinical features of early-onset parkinsonism patients with and without diurnal fluctuation.

Keywords

Diurnal Fluctuation Mental Symptom Sleep Benefit Familial Trait Truncal Dystonia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Yasuhiro Yamamura
    • 1
  • Tatsuo Kohriyama
    • 2
  • Yumiko Kaseda
    • 2
  • Hideshi Kawakami
    • 2
  • Sadao Katayama
    • 2
  • Tsutomu Yanagi
    • 3
  • Masao Uchida
    • 4
  • Toshio Nakahara
    • 5
  • Shigeki Kuzuhara
    • 6
  • Shigenobu Nakamura
    • 2
  1. 1.Institute of Health SciencesHiroshima University School of MedicineMinami-ku, Hiroshima #734Japan
  2. 2.Third Department of Internal MedicineHiroshima University School of MedicineMinami-ku, Hiroshima #734Japan
  3. 3.Nagoya Second Red Cross HospitalShowa-ku, Nagoya #466Japan
  4. 4.Tohsei HospitalSeto, #789Japan
  5. 5.Nakahara ClinicDanbara-cho Minami-ku, Hiroshima #734Japan
  6. 6.Deparment of NeurologyMie University School of MedicineTsu #574Japan

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