Pattern of Midbrain Pathology in Different Parkinsonian Syndromes
It is well established that the pattern of cell loss in Parkinson’s disease (PD) is not uniform throughout the pigmented cell clusters of the substantia nigra. In fact the regional selectivity of degeneration of the pigmented cell clusters in the human substantia nigra is quite striking (Hassler, 1938; Greenfield and Bosanquet, 1953; Bernheimer et al., 1973; Fearnley and Lees, 1991; Gibb and Lees, 1991). Furthermore, the topography of cell loss in patients with different clinical presentations is reported to correlate with specific clinical symptoms (Rinne et al., 1989; Fearnley and Lees, 1991; Paulus and Jellinger, 1991), such that ventrolateral cell loss correlates with rigidity and akinesia while medial cell loss correlates with dementia. The present study extends these clinicopathological correlations by examining the topography of cell loss in patients with similar clinical presentations but varying courses of the disease.
KeywordsSubstantia Nigra Cell Loss Cell Cluster Parkinsonian Syndrome Similar Clinical Presentation
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