The Amygdalostriatal Projection

An Analysis of Synaptic Inputs to GABAergic Interneuron Subtypes
  • Abbas F. Sadikot
  • Teresa M. Rudkin
  • Yoland Smith
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)

Abstract

The striatum receives massive inputs from the cortex, thalamus and midbrain, and is also afferented by serotoninergic and noradrenergic cells groups, and the globus pallidus (Heimer et al. 1995; Parent, 1990, for reviews). Recent studies have revealed a dense amygdalostriatal projection which is centered upon the nucleus accumbens, but which tographically distributes over a large striatal area excluding the sensorimotor sector (Wright and Groenewegen, 1995; Johnson et al., 1994a,b; McDonald et al, 1991; Kita and Kitai, 1990; Russchen and Price, 1984; Groenewegen et al, 1982, 1980; Kelley et al., 1982; DeFrance et al., 1980; Krettek and Price,1978; Dafny et al. 1975; de Olmos, 1972). In rodents, the amygdalostriatal projection arises mainly from the basolateral nuclear complex. Other amygdala nuclei contributing to the projection include the accessory basal and cortical nuclei, the amygdalohippocampal transitional area, and the nucleus of the lateral olfactory tract. These inputs are excitatory and use glutamate as a neurotransmitter (Callaway et al., 1991; Robinson and Beart, 1988; Christie et al, 1987; Fuller et al., 1987). As is true for cortical projections to the dorsal and ventral striatum (Sesack and Pickel, 1992; Totterdell and Smith, 1989; Dubé et al, 1988; Frotscher et al.,’ 81; Somogyi et al,’ 81; Kemp and Powell,’ 71), amygdala projections terminate mainly on dendritic spines of medium spiny neurons (Johnson et al., 1994a,b; Kita and Kitai, 1990).

Keywords

Nucleus Accumbens Dendritic Spine Projection Neuron Ventral Striatum Medium Spiny Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Abbas F. Sadikot
    • 1
  • Teresa M. Rudkin
    • 1
  • Yoland Smith
    • 2
  1. 1.Division of Neurosurgery, Department of Neurology and Neurosurgery, Montreal Neurological Institute, Faculy of MedicineMcGill UniversityMontrealCanada
  2. 2.Centre de Recherche en Neurobiologie, Enfant-Jésus Hospital, Faculty of MedicineLaval UniversityQuebecCanada

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