Single Unit Activity of the Human Globus Pallidus during Verbally Cueing Voluntary Movement
The activity of 513 units in external and internal segments of the human Globus Pallidus (GPe, GPi) analyzed during 24 stereotactic operations in parkinsonian patients made it possible to clarify the characteristics of the evoked activity of pallidal units during the performance of a verbally cueing motor tasks and to reveal the role of GP in the organization of voluntary movement in man.
Microelectrode recordings as the physiological identification of some thalamic nuclei and pallidum required during stereotactic operations for the treatment of parkinsonism (Lenz et al., 1990; Tasker et al., 1987; Raeva, 1986, 1972; Ohye, 1982; Jasper and Bertrand, 1966; Albe-Fessard et al., 1962) provide a unique opportunity to investigate how information for a verbally cueing voluntary movement is processed in human single neurons (Raeva, 1986, 1978, 1977, 1972). The aim of the present study was to analyze the characteristics of evoked activity (EA) patterns of pallidal units during the performance of a goal-directed movement in response to verbal commands and to reveal the role of the Globus Pallidus (GP) in processing of the motor information in awake human brain.
KeywordsGlobus Pallidus Thalamic Nucleus Voluntary Movement Wrist Flexion Verbal Command
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- Albe-Fessard, D., Arfel, G., Guiot, G., Hardy, J., Vourch, G., Hertzog, E., Aleonard, P., and Derome, P., 1962, Dérivations d’activités spontanées et evoquées dans les structures cérébrales profondes de l’homme, Rev.Neurol. 106: 89–105.Google Scholar
- DeLong, M.R., Crutcher, M.D., and Georgopoulos. A.P., 1985, Primate globus pallidus and subthalamic nucleus: functional organization, J.Neurophys. 53: 530–543.Google Scholar
- Jasper, H.H., and Bertrand, G., 1966, Thalamic units involved in somatic sensation and voluntary movement in man., in: The Thalamus, (D.P. Purpura, and M.D. Yahr, eds.), Columbia University Press, New York, pp.365–390.Google Scholar
- Nambu, A., Yoshida, S., Tambuchi, I., and Jinnai, K., 1993, Movement-related activity in the pallido-thalamocortical loop, Biomed. Res. 14, Suppl. 1, pp.31–35.Google Scholar
- Ohye, C., 1982, Depth microelectrode studies. In: Stereotaxy of the human brain. Anatomical, Physiological and clinical applications, (G. Schaltenbrand, and A.E. Walker, eds.), Georg Thieme Verlag, Stuttgart and New York, pp.372–389.Google Scholar
- Raeva, S., 1972, Unit activity of some deep nuclear structures of the human brain during voluntary movements. in: Neurophysiology studied in man, (G. Somjen, ed.), Excerpta Medica, Amsterdam, pp. 64–78.Google Scholar
- Raeva, S., 1977, Microelectrode investigations of unit activity of the human brain, (in russian). Nauka, Moscow, p. 208.Google Scholar
- Raeva, S., 1978, Role of neurons of the neostriatum and nonspecific thalamus in the organization of goal-directed activity, Human Physiology, Plenum Publishing Corporation, New York, 3(6): 769–780.Google Scholar
- Tasker, R.R., Lenz, F.A., Dostrovsky, G.O., Yamashiro, K., Chodakiewitz, G., and Albe-Fessard, D., 1987, The physiological basis of Vim thalamotomy for involuntary movement disorders, in: Clinical aspects of sensory and motor integration, (A. Struppler, and A. Weindle, eds.), Springer-Verlag, Berlin, Heidelberg, pp. 265–276.CrossRefGoogle Scholar